Humoral Transplantation Antibodies Play a Role in Protracted Rejection of Murine Renal Allografts
| Autor: | N. Niesen, B. Albini, K. Inoue, F. Milgrom |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Cytotoxicity
Immunologic Graft Rejection Pathology medicine.medical_specialty Kidney Glomerulus Immunology Antigen-Antibody Complex urologic and male genital diseases Peripheral blood mononuclear cell Mice Immune system Isoantibodies medicine Animals Immunology and Allergy Kidney biology business.industry Immune deposits General Medicine Kidney Transplantation Transplantation surgical procedures operative medicine.anatomical_structure Humoral immunity biology.protein Renal allograft Antibody business |
| Zdroj: | International Archives of Allergy and Immunology. 96:253-258 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000235503 |
| Popis: | Murine renal allografts were studied using (C57BL/6J × A/J)F1 mice as recipients and DBA/2 mice as donors. In this strain combination, protracted rejection was noted in that the circulation was maintained in the graft for over 10 weeks. In all grafts examined after 3 weeks, mononuclear cell infiltrates were noted; in addition, all grafts had immune deposits, apparently containing transplantation antibodies, in glomeruli, tubuli and vessels. These results stressed the role of humoral immunity in protracted renal allograft rejection. |
| Databáze: | OpenAIRE |
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