Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells

Autor:	Cai Ping Koh, Avinash Govind Bahirvani, Chelsia Qiuxia Wang, Tomomasa Yokomizo, Cherry Ee Lin Ng, Linsen Du, Vinay Tergaonkar, Dominic Chih-Cheng Voon, Hiroaki Kitamura, Hiroki Hosoi, Takashi Sonoki, Mok Meng Huang Michelle, Lii Jye Tan, Akiko Niibori-Nambu, Yi Zhang, Archibald S. Perkins, Zakir Hossain, Daniel G. Tenen, Yoshiaki Ito, Byrappa Venkatesh, Motomi Osato
Rok vydání:	2023
Předmět:	Mice Kinetics Adult Stem Cells Fetus Core Binding Factor Alpha 2 Subunit Genetics Animals Mice Transgenic General Medicine Hematopoietic Stem Cells Genetic Engineering
Zdroj:	Gene. 851:147049
ISSN:	0378-1119
DOI:	10.1016/j.gene.2022.147049
Popis:	A cis-regulatory genetic element which targets gene expression to stem cells, termed stem cell enhancer, serves as a molecular handle for stem cell-specific genetic engineering. Here we show the generation and characterization of a tamoxifen-inducible CreER
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8e1e2f6ef13f4828e21c4e4419664f https://doi.org/10.1016/j.gene.2022.147049 Zobrazit plný text záznamu Full Text from ScienceDirect