Hyperzincuria in insulin treated diabetes mellitus—its relation to glucose homeostasis and insulin administration
| Autor: | S. Kiilerich, Claus Christiansen, M. S. Christensen, Peter McNair, Sten Madsbad, Ib Transbøl |
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| Rok vydání: | 1981 |
| Předmět: |
Adult
Blood Glucose Male Glycosuria medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry chemistry.chemical_element Zinc Biochemistry Excretion chemistry.chemical_compound Internal medicine Diabetes Mellitus medicine Homeostasis Humans Insulin Glucose homeostasis Aged Creatinine Proteinuria business.industry Biochemistry (medical) General Medicine Middle Aged Endocrinology Diabetic diet chemistry Female medicine.symptom business |
| Zdroj: | Clinica Chimica Acta. 112:343-348 |
| ISSN: | 0009-8981 |
| Popis: | In order to elucidate some pathogenic factors of diabetic hyperzincuria we studied 60 adult insulin treated diabetic out-patients (40 males and 20 females), all with normal serum creatinine concentrations and absence of proteinuria during a 24-h period. Diabetic males and females both had significantly (p less than 0.01) increased zinc excretion rates (1.14 +/- 0.06 (S.E.M.) mumol/mmol creatinine and 1.37 +/- 0.10 mumol/mmol creatinine) compared with normal males and females (0.55 +/- 0.06 and 0.48 +/- 0.08, respectively). The urinary zinc excretion rate correlated positively with the degree of glycosuria (r = 0.36, p less than 0.01), but was not associated with the duration of the disease. However, serum zinc levels gave no evidence of a state of zinc depletion in these patients. It was calculated that zinc originating from a diabetic bone loss and the exogenous insulin administration accounted for only a small part of the hyperzincuria. Compensatory hyperabsorption and/or increased zinc content in the diabetic diet may therefore serve to explain the lack of zinc depletion in the presence of hyperzincuria. |
| Databáze: | OpenAIRE |
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