Sensitization by dihydrotachysterol (DHT) and calcium acetate for the induction of cardiac lesions by various agents
| Autor: | Hans Selye, S. Renaud, Eörs Bajusz, Yvette Lemire |
|---|---|
| Rok vydání: | 1959 |
| Předmět: |
medicine.medical_specialty
Renal cortex Sodium chemistry.chemical_element Calcium Acetates Cardiovascular calcification Oral administration Internal medicine Medicine Humans Denervation business.industry Calcium Compounds medicine.disease Myocarditis medicine.anatomical_structure Endocrinology chemistry Cardiovascular Diseases Dihydrotachysterol Nephrocalcinosis Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | American heart journal. 57(1) |
| ISSN: | 0002-8703 |
| Popis: | Calcium acetate can replace sodium phosphate as a sensitizing agent that permits the production of severe cardiovascular and renal lesions with otherwise ineffective doses of dihydrotachysterol (DHT). Still, the effect of the two electrolytes is not the same. Under the influence of DHT, sodium phosphate induces comparatively little cardiac and vascular calcification, much suppurating myocarditis, and a type of nephrocalcinosis that is primarily characterized by the formation of calcium casts within the tubular lumina at the corticomedullary junction line. On the other hand, under the same conditions, calcium acetate induces only mild myocarditic changes, much calcium deposition in the cardiovascular system, and a type of nephrocalcinosis that is almost exclusively limited to the stroma of the renal cortex. In rats simultaneously treated with comparatively small doses of DHT plus calcium acetate the resulting cardiovascular lesions can be considerably aggravated by a variety of stressor agents (cold baths, restraint, motor denervation). Furthermore, although noradrenalin does not normally produce any cardiovascular calcification in the rat, it is higly effective in this respect when the animal is pretreated with comparatively small doses of DHT plus calcium acetate. Finally, the oral administration of corn oil or glucose likewise aggravates the cardiovascular effects of DHT plus calcium acetate intoxication; these dietary supplements also act upon the course of the DHT plus calcium acetate syndrome in the same manner as they were previously shown to act upon the cardiopathy induced by corticoids plus sodium salts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|