Alcohol exposure before pregnancy: effect on GABA levels and turnover in rat offspring
| Autor: | Marc Ledig, Lucien Ciesielski, S. Simler, Paul Mandel |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Offspring Central nervous system Fetal alcohol syndrome Hypothalamus Mothers Biology Hippocampus gamma-Aminobutyric acid Pregnancy Internal medicine medicine Animals Rats Wistar Fetus Brain Mapping Ethanol Brain General Medicine Olfactory Pathways medicine.disease Olfactory Bulb Olfactory bulb Frontal Lobe Rats Endocrinology medicine.anatomical_structure Animals Newborn Fetal Alcohol Spectrum Disorders Gestation Female medicine.drug |
| Zdroj: | Alcohol and alcoholism (Oxford, Oxfordshire). 28(2) |
| ISSN: | 0735-0414 |
| Popis: | The GABA levels and turnover rates in various brain areas from 2-month-old rats born to mothers who consumed 20% (v/v) alcohol during 1 month only before pregnancy, were investigated. A decreased level was found in the olfactory tubercules and an increase was observed in the hypothalamus. The turnover rates were reduced in both areas, whereas an increase was observed in the frontal cortex. These results indicate that biochemical alterations may occur in the offspring even if the fetus did not develop under alcoholization. |
| Databáze: | OpenAIRE |
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