Fetal Growth Retardation due to Maternal Tobacco Smoke Exposure in the Rat
| Autor: | Pedro Rosso, William A. Blanc, L S James, Jorge A. Bassi, Adrien C. Moessinger |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Litter Size Offspring Birth weight Physiology Tobacco smoke Pregnancy Internal medicine medicine Animals Lung Maternal-Fetal Exchange Smoke Fetus Fetal Growth Retardation business.industry Smoking Fetal Body Weight Rats Inbred Strains DNA Organ Size medicine.disease Rats Endocrinology Liver Pediatrics Perinatology and Child Health RNA Gestation Female Tobacco Smoke Pollution business |
| Zdroj: | Pediatric Research. 18:127-130 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198402000-00002 |
| Popis: | Summary: Smoking during pregnancy results in offspring with an average birth weight 200 g less than those of non-smoking mothers. The pathogenesis of this effect is still unknown and there is no general agreement about the causal relationship between maternal smoking and subsequent fetal growth retardation. In the present study, a model of maternal smoking during pregnancy in the rat was established using the P & I Walton Exposure Machine. The study consisted of three groups: control, pair-fed, and smokeexposed. Smoke-exposed animals were exposed continuously to tobacco smoke for cycles of 7 min, 16 times a day from d 5 to d 20 of gestation. On d 21 of gestation, fetuses from all groups were removed by cesarean section, weighed, and dissected. The fetal brain, liver, and lungs as well as the placentas were weighed and analyzed for nucleic acid content. Fetal weight was found to be significantly reduced in both pair-fed and smoke-exposed groups compared with the control group. There was also a significant reduction in fetal body weight of the animals in the smoke-exposed group in comparison to those in the pair-fed group. Exposing the mother to smoke affected neither fetal brain weight nor nucleic acid content whereas fetal liver and lungs showed a significant decrease in both weight and nucleic acid content. These results indicate that the fetal growth retardation associated with maternal exposure to tobacco smoke in the rat corresponds to a disproportionate type. In addition, the present results indicate that the maternal tobacco smoke exposure induced fetal growth retardation without placental growth retardation. |
| Databáze: | OpenAIRE |
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