Interaction of RNA polymerase mutations in haploid and merodiploid cells of Escherichia coli K-12
| Autor: | M. I. Ovadis, Zh. M. Gorlenko, S. Z. Mindlin, R. B. Khesin, T. S. Ilyina |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Genetics
Microbial Mutant Haploidy Biology medicine.disease_cause chemistry.chemical_compound RNA polymerase Escherichia coli polycyclic compounds Genetics medicine heterocyclic compounds Molecular Biology Polymerase chemistry.chemical_classification Mutation Drug Resistance Microbial RNA Nucleotidyltransferases Chromosomes Bacterial biochemical phenomena metabolism and nutrition bacterial infections and mycoses Diploidy Virology Molecular biology Enzyme chemistry Conjugation Genetic biology.protein bacteria Rifampin Streptolydigin Rifampicin medicine.drug |
| Zdroj: | Molecular and General Genetics MGG. 110:118-133 |
| ISSN: | 1432-1874 0026-8925 |
| Popis: | Combination in the same chromosome of tsX mutation which affects the attachment of RNA polymerase to DNA template with either of two rifampicin resistant mutations (rif-r-1 or rif-r-5) is lethal. However tsX forms viable combination with other rifampicin resistant mutation—rif-r-76. Moreover a partial restoration of rifampicin binding capacity takes place: RNA polymerase from double tsX rif-r-76 mutant binds rifampicin better than the enzyme from tsX+ rif-r-76 cells. No mutual influence of rifampicin resistant and streptolydigin resistant mutations was found. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink