Circulating cytokines are associated with human islet graft function in type 1 diabetes
| Autor: | C. Pfleger, Reinhard G. Bretzel, Volker Burkart, C. Jaeger, Mathias D. Brendel, M. Eckhard, Nanette C. Schloot, Viktor Hogenkamp |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_treatment Immunology Islets of Langerhans Transplantation Mycophenolic acid Adrenal Cortex Hormones Azathioprine Humans Immunology and Allergy Medicine Kidney transplantation Antilymphocyte Serum Type 1 diabetes geography Islet cell transplantation geography.geographical_feature_category business.industry Interleukin Mycophenolic Acid medicine.disease Islet Kidney Transplantation Transplantation Diabetes Mellitus Type 1 surgical procedures operative Cytokine Cyclosporine Cytokines Female business Immunosuppressive Agents medicine.drug |
| Zdroj: | Clinical Immunology. 138:154-161 |
| ISSN: | 1521-6616 |
| Popis: | Islet cell transplantation has considerable potential as a cure for type 1 diabetes, but recurrent autoimmunity and allograft rejection in which both cytokines play an important role are major obstacles. Using a new approach considering confounders by regression analysis, we investigated circulating cytokines and their association with graft function in type 1 diabetes patients who underwent either simultaneous islet kidney (SIK) or islet after kidney (IAK) transplantation. After transplantation, interleukin (IL)-10 was lower in SIK recipients with subsequent loss of graft function in comparison to recipients maintaining graft function. Before transplantation, high IL-13 and IL-18 concentrations were prospectively associated for subsequent loss of graft function in IAK recipients, whereas in SIK recipients, high macrophage migration inhibitory factor (MIF) concentrations were associated with subsequent loss of graft function. Circulating cytokines are associated with islet graft function in patients with long-standing type 1 diabetes when considering confounders. |
| Databáze: | OpenAIRE |
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