Hypofractionated radiotherapy for breast cancer patients treated by breast-conserving surgery: short-term morbidity and preliminary results
| Autor: | Maria-Aikaterini Theofanopoulou, Georgios Kyrgias, Konstantinia Sotiriadou, Georgios Plataniotis |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Oncology medicine.medical_specialty medicine.medical_treatment Breast surgery Breast Neoplasms Mastectomy Segmental Breast cancer Surgical oncology Internal medicine medicine Breast-conserving surgery Humans Neoplasm Invasiveness Pharmacology (medical) Radiology Nuclear Medicine and imaging Survival rate Aged Neoplasm Staging business.industry Carcinoma Ductal Breast Dose fractionation General Medicine Middle Aged Prognosis medicine.disease Survival Rate Radiation therapy Carcinoma Lobular Treatment Outcome Female Radiotherapy Adjuvant Dose Fractionation Radiation Lymph Nodes Morbidity business Mastectomy Follow-Up Studies |
| Zdroj: | Breast Cancer. 17:42-47 |
| ISSN: | 1880-4233 1340-6868 |
| Popis: | Hypofractionated adjuvant radiotherapy (RT) in breast cancer patients treated by conservative surgery has been increasingly used in recent years. We present our experience regarding tolerance/acute toxicity of a hypofractionated RT schedule.We report on 339 patients treated for 4 years (March 2003-2007) by 42.5 Gy/16 fractions at the RT Department of Larissa University Hospital. Electron boost of 9-10 Gy/3-4 fractions was given to 104/339 (31%). Axillary/supraclavicular RT was given to the node-positive patients with the same fractionation schedule. Median follow-up time was 24 months.RTOG grades 0, 1, 2, 3, and 4 for acute skin toxicity were 9.7, 68.7, 17.5, 4, and 0.3%, respectively. Radiation pneumonitis (resolved promptly by steroids) was suspected/diagnosed in 11/339 (3.2%). A total of 8/11 had been treated by regional lymphatics RT. In the univariate analysis, the following variables were examined as predictive of skin (grade1) and lung (any grade) reactions: age, chemotherapy, endocrine treatment, RT of regional lymphatics, and boost RT. The only significant correlation was that of radiation pneumonitis and RT of regional lymphatics (Fisher's exact test, P = 0.000).Our current results are similar to those from other centers, although they need to be evaluated for a longer time. This fractionation seems to be effective with acceptable side effects, while it facilitates the treatment for both patients and RT centers. |
| Databáze: | OpenAIRE |
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