Treatment and re-characterization of mouse obstructive genitourinary syndrome
| Autor: | Clara Muñoz-Mediavilla, Paloma Rey, Alicia Sanchez, María Jesús Molina-Cimadevila, Ana M. Wägner, Tomás García-Robles, Yeray Brito-Casillas |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Animal breeding Urethral Obstruction Foreskin Preputial gland Male mice Rodent Diseases 03 medical and health sciences Mice Semen Medicine Animals Pathological General Veterinary business.industry Genitourinary system Limiting Breed Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Fertility Spain Animal Science and Zoology Female business Penis |
| Zdroj: | Lab animal. 45(6) |
| ISSN: | 1548-4475 |
| Popis: | We aimed to characterize and to explore a treatment for a condition in which male mice exhibited a solid bulge in the preputial area and an inability to breed. Twenty-seven mice from several animal housing institutions in Spain were included in this study for microbiological and pathological characterization of this condition. The condition mostly affected breeding animals and was associated with the C57BL/6J genetic background. A solid, yellowish-white substance was found inside the prepuce, which displaced the penis cranially, preventing its externalization and limiting the animal's capacity to breed. This pattern was almost identical to that of post-coital vaginal plugs, suggesting that the blocking substance originated from ejaculate. Opposite to what was suggested in previous publications, the penis was completely intact in all of the cases, with no signs of mutilation or wounds. Based on our findings, we developed a surgical technique to clear the prepuce and recover breeding performance, which we tested in 15 other mice with the condition. We eliminated the blocking substance and recurrence of the condition by surgically opening the prepuce, and most of the animals recovered fertility. |
| Databáze: | OpenAIRE |
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