Cellular and molecular oxidative stress-related effects in uterine myometrial and trophoblast-decidual tissues after perigestational alcohol intake up to early mouse organogenesis
| Autor: | Tamara Anahí Coll, María del Carmen Ríos de Molina, Leticia Gabriela Pérez-Tito, Elisa Cebral, Martín Ricardo Ventureira, Gabriela Chaufan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endothelium Otras Ciencias Biológicas Organogenesis CELLULAR AND TISSUE DAMAGE Clinical Biochemistry Biology medicine.disease_cause Ciencias Biológicas Mice 03 medical and health sciences chemistry.chemical_compound PERIGESTATIONAL ALCOHOL Pregnancy Placenta Internal medicine Decidua medicine Animals PLACENTA OXIDATIVE STRESS Molecular Biology Myometrium Trophoblast DECIDUA Cell Biology General Medicine Glutathione Trophoblasts MOUSE ORGANOGENESIS Oxidative Stress 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Fetal Alcohol Spectrum Disorders Maternal Exposure Gestation Female CIENCIAS NATURALES Y EXACTAS Oxidative stress |
| Zdroj: | Molecular and Cellular Biochemistry. 440:89-104 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/s11010-017-3158-y |
| Popis: | The placenta plays a major role in embryo-fetal defects and intrauterine growth retardation after maternal alcohol consumption. Our aims were to determine the oxidative status and cellular and molecular oxidative stress effects on uterine myometrium and trophoblast-decidual tissue following perigestational alcohol intake at early organogenesis. CF-1 female mice were administered with 10% alcohol in drinking water for 17 days prior to and up to day 10 of gestation. Control females received ethanol-free water. Treated mice had smaller implantation sites compared to controls (p |
| Databáze: | OpenAIRE |
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