Structural Perspective of BMP ligands and Signaling
| Autor: | Jason C. McCoy, Gregory Royce Gipson, Emily C. Kappes, Kaitlin N. Hart, Thomas B. Thompson, Erich J Goebel, Chandramohan Kattamuri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell signaling Histology Physiology Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Computational biology Bone morphogenetic protein Ligands Article 03 medical and health sciences 0302 clinical medicine Molecular level Bmp signaling medicine Humans Pulmonary Arterial Hypertension biology Transforming growth factor beta medicine.disease 030104 developmental biology Myositis Ossificans Fibrodysplasia ossificans progressiva Bone Morphogenetic Proteins biology.protein Signal Transduction |
| Zdroj: | Bone |
| Popis: | The Bone Morphogenetic Proteins (BMPs) are the largest class signaling molecules within the greater Transforming Growth Factor Beta (TGFβ) family, and are responsible for a wide array of biological functions, including dorsal-ventral patterning, skeletal development and maintenance, as well as cell homeostasis. As such, dysregulation of BMPs results in a number of diseases, including fibrodysplasia ossificans progressiva (FOP) and pulmonary arterial hypertension (PAH). Therefore, understanding BMP signaling and regulation at the molecular level is essential for targeted therapeutic intervention. This review discusses the recent advances in the structural and biochemical characterization of BMPs, from canonical ligand-receptor interactions to co-receptors and antagonists. This work aims to highlight how BMPs differ from other members of the TGFβ family, and how that information can be used to further advance the field. Lastly, this review discusses several gaps in the current understanding of BMP structures, with the aim that discussion of these gaps will lead to advancements in the field. |
| Databáze: | OpenAIRE |
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