Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-Analysis

Autor: Sebastian Lundström, Marjo-Riitta Järvelin, Henning Tiemeier, Cathryn M. Lewis, Ville Karhunen, Andrea G. Allegrini, Ralf Kuja-Halkola, Jouke-Jan Hottenga, Anita Thapar, Bart M. L. Baselmans, Alexandra Havdahl, Helga Ask, Eshim S. Jami, Martin Steen Tesli, Fernando Rivadeneira, Elizabeth W Diemer, Christel M. Middeldorp, Per Magnus, Wonuola A. Akingbuwa, Ragna Bugge Askeland, Ted Reichborn-Kjennerud, Hamdi Mbarek, Kaili Rimfeld, Fiona A. Hagenbeek, Michel G. Nivard, Eivind Ystrom, Paul Lichtenstein, Marcus R. Munafò, Gerome Breen, Robert Plomin, Anke R. Hammerschlag, Hannah M Sallis, Catharina E. M. van Beijsterveldt, Meike Bartels, Dorret I. Boomsma
Přispěvatelé: Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, APH - Personalized Medicine, APH - Methodology, Commission of the European Communities, Child and Adolescent Psychiatry / Psychology, Epidemiology, Internal Medicine
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Netherlands Twin Register (NTR)
Multifactorial Inheritance
Bipolar Disorder
1702 Cognitive Sciences
Behavioral Symptoms
Personal Satisfaction
POLYGENIC SCORES
Body Mass Index
0302 clinical medicine
Sleep Initiation and Maintenance Disorders
Medicine
Longitudinal Studies
RATING-SCALE
Child
MoBa
Psychiatry
RISK
Generation R
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
and the Bipolar Disorder and Major Depressive Disorder Working Groups of the Psychiatric Genomics Consortium
PSYCHIATRIC-DISORDERS
ALSPAC
Neuroticism
3. Good health
Europe
TEDS
Psychiatry and Mental health
Major depressive disorder
Educational Status
Life Sciences & Biomedicine
Developmental psychopathology
Psychopathology
Clinical psychology
Adult
Adolescent
Child psychopathology
polygenic risk score (PRS)
Childhood psychopathology
NTR
BF
CATSS
03 medical and health sciences
Young Adult
Genetics
Attention deficit hyperactivity disorder
Humans
Bipolar disorder
GENOME-WIDE ASSOCIATION
Social Behavior
MODEL SELECTION
EDUCATIONAL-ATTAINMENT
Depressive Disorder
Major
Science & Technology
business.industry
MAJOR DEPRESSION
NFBC86
medicine.disease
030227 psychiatry
Mood disorders
1701 Psychology
Attention Deficit Disorder with Hyperactivity
RC0321
business
030217 neurology & neurosurgery
Meta analysis
1199 Other Medical and Health Sciences
Zdroj: JAMA Psychiatry, 77(7), 715-728. American Medical Association
Akingbuwa, W A, Hammerschlag, A R, Jami, E S, Allegrini, A G, Karhunen, V, Sallis, H, Ask, H, Askeland, R B, Baselmans, B, Diemer, E, Hagenbeek, F A, Havdahl, A, Hottenga, J-J, Mbarek, H, Rivadeneira, F, Tesli, M, van Beijsterveldt, C, Breen, G, Lewis, C M, Thapar, A, Boomsma, D I, Kuja-Halkola, R, Reichborn-Kjennerud, T, Magnus, P, Rimfeld, K, Ystrom, E, Jarvelin, M-R, Lichtenstein, P, Lundstrom, S, Munafò, M R, Plomin, R, Tiemeier, H, Nivard, M G, Bartels, M, Middeldorp, C M & and the Bipolar Disorder and Major Depressive Disorder Working Groups of the Psychiatric Genomics Consortium 2020, ' Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals : A Meta-analysis ', JAMA Psychiatry, vol. 77, no. 7, pp. 715-728 . https://doi.org/10.1001/jamapsychiatry.2020.0527
Akingbuwa, W, Hammerschlag, A, Jami, E, Allegrini, A, Karhunen, V, Sallis, H M, Ask, H, Askeland, R B, Baselmans, B M L, Diemer, E, Hagenbeek, F, Havdahl, K A, Hottenga, J-J, Mbarek, H, Rivadeneira, F, Tesli, M, van Beijsterveldt, C, Breen, G, Lewis, C, Thapar, A, Boomsma, D, Kuja-Halkola, R, Reichborn-Kjennerud, T, Magnus, P, Rimfeld, K, Ystrom, E, Järvelin, M-R, Lichtenstein, P, Lundström, S, Munafo, M R, Plomin, R, Tiemeier, HW, Nivard, M, Bartels, M & Middeldorp, C M 2020, ' Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals : A Meta-Analysis ', JAMA Psychiatry . https://doi.org/10.1001/jamapsychiatry.2020.0527
Print: 2168-622X
Akingbuwa, W A, Hammerschlag, A R, Jami, E S, Baselmans, B, Hagenbeek, F A, Hottenga, J-J, Mbarek, H, Boomsma, D I, Nivard, M G, Bartels, M, Middeldorp, C M & Bipolar Disorder and Major Depressive Disorder Working Groups of the Psychiatric Genomics Consortium 2020, ' Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals : A Meta-Analysis ', JAMA Psychiatry, vol. 77, no. 7, pp. 715-728 . https://doi.org/10.1001/jamapsychiatry.2020.0527
JAMA psychiatry
ISSN: 2168-622X
2168-6238
DOI: 10.1001/jamapsychiatry.2020.0527
Popis: Importance: Adult mood disorders are often preceded by behavioral and emotional problems in childhood. It is yet unclear what explains the associations between childhood psychopathology and adult traits.Objective: To investigate whether genetic risk for adult mood disorders and associated traits is associated with childhood disorders.Design, setting, and participants: This meta-analysis examined data from 7 ongoing longitudinal birth and childhood cohorts from the UK, the Netherlands, Sweden, Norway, and Finland. Starting points of data collection ranged from July 1985 to April 2002. Participants were repeatedly assessed for childhood psychopathology from ages 6 to 17 years. Data analysis occurred from September 2017 to May 2019.Exposures: Individual polygenic scores (PGS) were constructed in children based on genome-wide association studies of adult major depression, bipolar disorder, subjective well-being, neuroticism, insomnia, educational attainment, and body mass index (BMI).Main outcomes and measures: Regression meta-analyses were used to test associations between PGS and attention-deficit/hyperactivity disorder (ADHD) symptoms and internalizing and social problems measured repeatedly across childhood and adolescence and whether these associations depended on childhood phenotype, age, and rater.Results: The sample included 42 998 participants aged 6 to 17 years. Male participants varied from 43.0% (1040 of 2417 participants) to 53.1% (2434 of 4583 participants) by age and across all cohorts. The PGS of adult major depression, neuroticism, BMI, and insomnia were positively associated with childhood psychopathology (β estimate range, 0.023-0.042 [95% CI, 0.017-0.049]), while associations with PGS of subjective well-being and educational attainment were negative (β, -0.026 to -0.046 [95% CI, -0.020 to -0.057]). There was no moderation of age, type of childhood phenotype, or rater with the associations. The exceptions were stronger associations between educational attainment PGS and ADHD compared with internalizing problems (Δβ, 0.0561 [Δ95% CI, 0.0318-0.0804]; ΔSE, 0.0124) and social problems (Δβ, 0.0528 [Δ95% CI, 0.0282-0.0775]; ΔSE, 0.0126), and between BMI PGS and ADHD and social problems (Δβ, -0.0001 [Δ95% CI, -0.0102 to 0.0100]; ΔSE, 0.0052), compared with internalizing problems (Δβ, -0.0310 [Δ95% CI, -0.0456 to -0.0164]; ΔSE, 0.0074). Furthermore, the association between educational attainment PGS and ADHD increased with age (Δβ, -0.0032 [Δ 95% CI, -0.0048 to -0.0017]; ΔSE, 0.0008).Conclusions and relevance: Results from this study suggest the existence of a set of genetic factors influencing a range of traits across the life span with stable associations present throughout childhood. Knowledge of underlying mechanisms may affect treatment and long-term outcomes of individuals with psychopathology.
Databáze: OpenAIRE
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