Predictors of outcome in first-episode schizophrenia over the first 4 years of illness
| Autor: | Mary Clarke, O. McTigue, S. Browne, A. Kinsella, Eadbhard O'Callaghan, Peter Whitty, Conall Larkin, M. Kamali |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Psychosis Pediatrics medicine.medical_specialty Prognostic variable Time Factors Global Assessment of Functioning Severity of Illness Index Severity of illness medicine Humans Prospective Studies Psychiatry Prospective cohort study Applied Psychology First episode medicine.disease Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Treatment Outcome Schizophrenia dup Female Schizophrenic Psychology Psychology Follow-Up Studies |
| Zdroj: | Psychological Medicine. 38:1141-1146 |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundThe outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date.MethodWe conducted a first-episode follow-up study of 97 patients with DSM-IV schizophrenia over the first 4 years of illness. First presentation and follow-up assessments were compared using pairedttests and a forced-entry regression analysis was used to determine prognostic variables.ResultsThere were significant improvements in positive and negative symptoms and global assessment of functioning between first presentation and follow-up. At first presentation, fewer negative symptoms (t=−3.40,pt=3.25,pt=−2.77,pConclusionsThe outcome of schizophrenia may not be as pessimistic as once thought and most patients did not display a downward deteriorating course of illness. This study supports the relationship between DUP and outcome beyond the early stages of illness. |
| Databáze: | OpenAIRE |
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