Beta-Catenin Mutation Does Not Seem to Have an Effect on the Tumorigenesis of Pediatric Rhabdomyosarcomas
| Autor: | Stéphane Barrette, Jean-Christophe Fournet, Louise-Marie Giroux, Rocio Sanchez, Anne-Laure Rougemont, Riwa Absi, Dorothée Bouron-Dal Soglio |
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| Rok vydání: | 2009 |
| Předmět: |
Male
musculoskeletal diseases Hepatoblastoma Pathology medicine.medical_specialty Adolescent genetic structures Pancreatoblastoma Biology medicine.disease_cause Polymerase Chain Reaction Pathology and Forensic Medicine Exon Biomarkers Tumor medicine Humans Rhabdomyosarcoma Embryonal Child Rhabdomyosarcoma Rhabdomyosarcoma Alveolar beta Catenin Medulloblastoma Wnt signaling pathway Infant General Medicine musculoskeletal system medicine.disease Immunohistochemistry eye diseases Child Preschool Mutation Pediatrics Perinatology and Child Health Cancer research Female Carcinogenesis human activities Immunostaining |
| Zdroj: | Pediatric and Developmental Pathology. 12:371-373 |
| ISSN: | 1615-5742 1093-5266 |
| Popis: | Involvement of the Wnt signal transduction pathway has been shown in different pediatric embryonal tumors, such as hepatoblastoma, nephroblastoma, pancreatoblastoma, and medulloblastoma. There are few data available on the status of beta-catenin in rhabdomyosarcoma (RMS), another pediatric embryonal tumor. The aims of this study were 1st to verify the status of the exon 3 of CTNNB1 and 2nd to assess the usefulness of beta-catenin immunostaining in a small series of 8 embryonal RMS, 3 alveolar RMS, and 1 sclerosing RMS (SRMS). Sequence analysis revealed no mutations in the exon 3 of CTNNB1 in all the tumors studied. All RMS showed a cytoplasmic beta-catenin staining with cytoplasmic membrane reinforcement and no nuclear delocalization. We conclude that there is no evidence of beta-catenin mutation in the genesis of rhabdomyosarcoma and that beta-catenin does not represent a useful immunomarker to help distinguish between embryonal RMS and alveolar RMS. |
| Databáze: | OpenAIRE |
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