MK-927: a topically effective carbonic anhydrase inhibitor in patients
| Autor: | Alain M. Bron, F. Brunner-Ferber, Brigitte I. Feicht, Hans A. von Denffer, Hans M. Hofmann, Erik A. Lippa, Jean G. Royer, Deborah L. Panebianco |
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| Přispěvatelé: | Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon) |
| Jazyk: | angličtina |
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Intraocular pressure genetic structures medicine.drug_class Eye disease medicine.medical_treatment [SDV]Life Sciences [q-bio] Ocular hypertension Thiophenes Placebo Placebos 03 medical and health sciences Random Allocation 0302 clinical medicine Double-Blind Method Carbonic anhydrase Medicine Humans Carbonic anhydrase inhibitor Carbonic Anhydrase Inhibitors Intraocular Pressure Aged Aged 80 and over Clinical Trials as Topic Sulfonamides biology Eye Color business.industry Eye drop Middle Aged medicine.disease Crossover study eye diseases 3. Good health Ophthalmology Anesthesia 030221 ophthalmology & optometry biology.protein Female Ocular Hypertension sense organs Ophthalmic Solutions business 030217 neurology & neurosurgery Glaucoma Open-Angle |
| Zdroj: | Archives of Ophthalmology-New Series Archives of Ophthalmology-New Series-, American Medical Association, 1989, 107 (8), pp.1143-1146 |
| ISSN: | 0003-9950 |
| Popis: | International audience; The effects on intraocular pressure of the novel topical carbonic anhydrase inhibitor MK-927 were investigated for the first time in patients. Three drops of 2% MK-927 was administered in a two-center, double-masked, randomized, placebo-controlled, two-period crossover study in 25 patients with bilateral primary open angle glaucoma or ocular hypertension. At 4.5 hours after the dose, MK-927-treated eyes demonstrated a peak mean change of -7.7 mm Hg from a mean intraocular pressure of 27.8 mm Hg immediately before the dose; this compares with a change of -3.9 mm Hg from a mean intraocular pressure of 28.2 mm Hg when the same eyes were treated with placebo. The peak mean percent change in intraocular pressure in eyes treated with MK-927 was -26.7% at 6 hours after the dose compared with a change of -13.7% after treatment with placebo. No contralateral effect on intraocular pressure due to MK-927 was observed. |
| Databáze: | OpenAIRE |
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