A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients
| Autor: | Ryuichi Hasegawa, Hironobu Akao, Keiko Maekawa, Tatsuro Ishida, Yoshiro Saito, Kenji Takeda, Kouichi Kurose, Takashi Tanimoto, Keijiro Saku, Takashi Yamano, Kouji Kajinami, Kimie Sai, Aya Shiraki, Masafumi Ueno, Shusuke Yagi, Shunichi Miyazaki, Koichi Sugamura, Mizuho Iwadare, Ken-ichi Hirata, Masataka Sata, Yasuyuki Kawai, Koichi Node, Jun-ichi Oyama, Takuya Imatoh, Takashi Akasaka, Ryoko Sato-Ishida, Takeshi Soeki, Hisao Ogawa, Y. Matsuzawa |
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| Rok vydání: | 2016 |
| Předmět: |
Genetic Markers
Male musculoskeletal diseases Oncology medicine.medical_specialty Pathology Pharmaceutical Science 030226 pharmacology & pharmacy Rhabdomyolysis 03 medical and health sciences 0302 clinical medicine Japan Muscular Diseases Internal medicine medicine Humans Pharmacology (medical) Clinical significance Adverse effect Myopathy Allele frequency Aged Pharmacology Myositis biology business.industry Myalgia Odds ratio Middle Aged Confidence interval 030220 oncology & carcinogenesis biology.protein Female Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom SLCO1B1 business human activities Pharmacogenetics HLA-DRB1 Chains |
| Zdroj: | Drug Metabolism and Pharmacokinetics. 31:467-470 |
| ISSN: | 1347-4367 |
| Popis: | Statin-related myopathy (SRM) is a clinically important adverse reaction. Recent pharmacogenetic research, mainly in non-Asian populations, have indicated clinical relevance of some of genetic biomarkers to SRM, but predictive markers for SRM in Asian populations including Japanese has not yet been established. This study was aimed to identify clinically important genetic markers associated with SRM in Japanese patients. Allele frequencies of the three reported candidate markers — SLCO1B1 rs4149056, RYR2 rs2819742, and GATM rs9806699 — and carrier frequencies of HLA types were compared between patients with SRM patients (n = 52) and healthy Japanese subjects (n = 2878 or 86 (for rs9806699) as controls). No significant association of RYR2, SLCO1B1, and GATM variants with SRM were observed in our Japanese patients, but a significant association was detected for HLA-DRB1*04:06 with SRM (odds ratio: 3.19; 95% confidence interval: 1.53–6.66). This study suggested that HLA-DRB1*04:06 might be associated with SRM onset in a Japanese population. Further studies are required to validate these results. |
| Databáze: | OpenAIRE |
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