DIRECT INHIBITION OF GASTRIC ACID BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN DOGS
| Autor: | Jeremy Hugh Baron, S.R. Bloom, A. A. J. Barros D'Sa |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Time Factors chemistry.chemical_compound Dogs Internal medicine Growth hormone release inhibiting hormone Animals Medicine Infusions Parenteral Gastrin Parietal cell Meal Gastric Juice business.industry digestive oral and skin physiology Gastric Acidity Determination General Medicine Animal Feed Pentagastrin medicine.anatomical_structure Endocrinology chemistry Gastric acid Somatostatin business Histamine Hormone medicine.drug |
| Zdroj: | The Lancet. 305:886-887 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(75)91685-2 |
| Popis: | To find out if growth-hormone release- inhibiting hormone (G.H.-R.I.H.) had any direct action on gastric acid production independent of its effect on gastrin release, cyclic G.H.-R.I.H. was infused at a rate of 20 μg. per kg. per hour into dogs with gastric fistulae. Gastric acid output fell sharply in response to three stimuli of acid production—a meal and pentagastrin and histamine infusions. The fact that acid output was inhibited during pentagastrin administration suggests that G.H.-R.I.H. has a direct action on the gastric parietal cell. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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