Are Soy Products Effective in DMD?
| Autor: | Gemma Marston, Steve J. Winder |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Protease
business.industry medicine.medical_treatment Medicine (miscellaneous) Health benefits Pharmacology Isoflavones Soy bean Protease inhibitor (biology) 03 medical and health sciences Regimen chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Medicine Muscular Dystrophy business SOY ISOFLAVONES Tyrosine kinase 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | PLoS Currents |
| ISSN: | 2157-3999 |
| Popis: | Introduction. In addition to their nutritional value, processed soy bean extracts contain several activities with potential therapeutic benefits. These include anti-oxidants, and tyrosine kinase and protease inhibitory activity. There are also anecdotal reports of health benefits of soy products in alleviating DMD symptoms. Methods. Mdx mice were fed a control soy-free diet or the same diet containing either a proprietary soy preparation (Haelan 951), purified soy isoflavones, purified Bowman-Birk protease inhibitor or a combination of isoflavones and Bowman-Birk inhibitor. Mice were tested for their wire hanging ability at the start of the diet regimen and every 4 weeks until week 12 of treatment. Results and Discussion. The diet containing Bowman-Birk inhibitor was the only one to show a significant and sustained improvement over the 12 weeks of the study. All other dietary additions; Haelan 951, isoflavones and isoflavones with Bowman-Birk inhibitor, were not significantly different from each other or from control. The effectiveness of Bowman-Birk inhibitor in mdx mice clearly warrants further study. |
| Databáze: | OpenAIRE |
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