Human Papillomavirus Types 16, 18, and 31 Share Similar Endocytic Requirements for Entry
| Autor: | Klaus Boller, Luise Florin, Bettina Frenzel, Lena Kühling, Gilles A. Spoden, Nicole Cordes, Martin Sapp, Mario Schelhaas |
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| Rok vydání: | 2013 |
| Předmět: |
viruses
Immunology Endocytic cycle Tetraspanin 24 Endocytosis Microbiology Clathrin Dynamin II Polymerization Membrane Microdomains Tetraspanin Virology Caveolin Humans Human papillomavirus 31 Lipid raft Dynamin Human papillomavirus 16 Microscopy Confocal Human papillomavirus 18 biology virus diseases Lysosome-Associated Membrane Glycoproteins Virus Internalization Actins Virus-Cell Interactions Cell biology Microscopy Electron Microscopy Fluorescence Insect Science biology.protein Electrophoresis Polyacrylamide Gel HeLa Cells |
| Zdroj: | Journal of Virology. 87:7765-7773 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.00370-13 |
| Popis: | Human papillomavirus type 18 (HPV18), one of the HPVs with malignant potential, enters cells by an unknown endocytic mechanism. The key cellular requirements for HPV18 endocytosis were tested in comparison to those for HPV16 and -31 endocytoses. HPV18 (like HPV16 and -31) entry was independent of clathrin, caveolin, dynamin, and lipid rafts but required actin polymerization and tetraspanin CD151, and the viruses were routed to the same LAMP-1-positive compartment. Hence, the viruses shared similar cellular requirements for endocytic entry. |
| Databáze: | OpenAIRE |
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