Arterial pressure-urinary output relationship in hypertensive rats
| Autor: | Arthur C. Guyton, J. A. Enobakhare, DeClue Jw, R. A. Norman, B. H. Douglas |
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| Rok vydání: | 1978 |
| Předmět: |
Urinary output
Mean arterial pressure medicine.medical_specialty Hypertension Renal Physiology Chemistry Sodium chemistry.chemical_element Blood Pressure Kidney Rats Blood pressure Endocrinology Physiology (medical) Torr Internal medicine Renal physiology Hypertension Renal mass medicine Potassium Animals medicine.symptom Vasoconstriction |
| Zdroj: | The American journal of physiology. 234(3) |
| ISSN: | 0002-9513 |
| Popis: | The steady-state relationship between mean arterial pressure (AP) and output of sodium and water was determined for one-kidney control (1KC), one-kidney Goldblatt (1KG), normotensive Wistar-Kyoto (WKY), and Okamoto spontaneously hypertensive rats (SHR). Control fluid intake (given by intravenous infusion) was set at approximately 30 ml/day Ringer solution. The infusion rate was then increased progressively to 2, 4, and 8 times control for 24- to 48-h periods each. Control AP averaged 115 Torr in 1KC, 152 Torr in 1KG, 120 Torr in WKY, and 158 Torr in SHR. The eightfold increase in salt and water intake was accompanied by almost equal increase in salt and water output and increases in AP to 157 Torr in 1KC, 190 Torr in 1KG, 126 Torr in WKY, and 166 Torr in SHR. The arterial pressure-urinary output relationship in 1KG is parallel to that of 1KC but shifted to higher AP levels. Similarly, this relationship in SHR is parallel to that of WKY but shifted to higher AP levels. This parallel shift is indicative of uniform renal vasoconstriction but normal functional renal mass in the SHR. |
| Databáze: | OpenAIRE |
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