Protein-mediated base flipping

Autor:	David P. Hornby, G. C. Ford
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Stereochemistry Biomedical Engineering Bioengineering Biology DNA methyltransferase chemistry.chemical_compound Enzyme chemistry Biochemistry Nucleic acid Base (exponentiation) Cytosine Biotechnology
Zdroj:	Current Opinion in Biotechnology. 9:354-358
ISSN:	0958-1669
Popis:	Since the discovery that the DNA methyltransferase M. Hha I utilises a base flipping mechanism to expose its target cytosine during catalysis, this phenomenon has been observed in other nucleic acid modifying enzymes. The crystallographic analyses of such enzyme—DNA complexes have revealed the molecular features of extrahelical base stabilisation, but have been less informative about the flipping process itself.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf77d8feb03548b48a2de6cf69a00b2c https://doi.org/10.1016/s0958-1669(98)80007-4 Zobrazit plný text záznamu Full Text from ScienceDirect