Associations between serum concentration of flavonoids and breast cancer risk among Chinese women
| Autor: | Lei Li, Luo-Shi-Yuan Zuo, Xiao-Xia Zhan, Cai-Xia Zhang, Xiao-Li Feng, Xin Zhang, Xiong-Fei Mo, Kai-Yan Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Naringenin medicine.medical_specialty China Medicine (miscellaneous) 030209 endocrinology & metabolism Breast Neoplasms Flavones 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Flavonols Breast cancer Risk Factors Internal medicine Medicine Humans Prospective Studies Prospective cohort study chemistry.chemical_classification Flavonoids 030109 nutrition & dietetics Nutrition and Dietetics business.industry Case-control study Odds ratio medicine.disease Diet chemistry Case-Control Studies Female business Kaempferol |
| Zdroj: | European journal of nutrition. 60(3) |
| ISSN: | 1436-6215 |
| Popis: | In vitro and in vivo studies suggested that flavonols, flavones, flavanones and flavan-3-ols have preventive effects on breast carcinogenesis. Epidemiological evidence about the associations between these flavonoid biomarkers and breast cancer risk is limited. This study aimed to investigate the association between serum concentration of these flavonoids and breast cancer risk among Chinese women. This hospital-based case–control study recruited 792 breast cancer cases and 813 age frequency-matched (5-year interval) controls who provided eligible blood samples in Guangdong Province, China. Ultra-high-performance liquid chromatography–tandem mass spectrometry was used to measure flavonoids. Unconditional logistic regression was used to estimate the odds ratio (OR) and 95% confidence internal (CI). Higher concentrations of serum flavonols, isorhamnetin, kaempferol, flavanones and naringenin were significantly associated with lower breast cancer risk, with adjusted ORs (95% CIs) for the highest versus the lowest group of 0.66 (0.49–0.89) for flavonols, 0.52 (0.38–0.70) for isorhamnetin, 0.60 (0.45–0.80) for kaempferol, 0.65 (0.49–0.87) for flavanones and 0.45 (0.34–0.60) for naringenin, respectively. Significant positive associations were observed between serum flavan-3-ols, epigallocatechin, epigallocatechin-3-gallate and breast cancer risk. No significant associations were observed for serum quercetin, flavones, apigenin, luteolin, hesperetin, catechin, epicatechin and epicatechin-3-gallate with overall breast cancer risk. This study suggested that serum flavonols and flavanones were inversely associated with breast cancer risk and serum flavan-3-ols were positively associated with breast cancer risk. Serum flavones were not associated with overall breast cancer risk. These findings warrant further confirmation in prospective studies. |
| Databáze: | OpenAIRE |
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