Idiopathic Hypereosinophilic Syndrome in Children: 3 Cases with Review of Literature
| Autor: | Jayashree Kanthila, Nalini Bhaskaranand |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Disease Asymptomatic Sepsis Hypereosinophilic Syndrome Biopsy medicine Humans Hydroxyurea Retrospective Studies medicine.diagnostic_test business.industry Gold standard Infant Retrospective cohort study medicine.disease medicine.anatomical_structure Child Preschool Liver biopsy Pediatrics Perinatology and Child Health Female Steroids Bone marrow medicine.symptom business |
| Zdroj: | The Indian Journal of Pediatrics. 80:124-127 |
| ISSN: | 0973-7693 0019-5456 |
| Popis: | To highlight the varied clinical manifestations and management of idiopathic hypereosinophilic syndrome, a rare disorder in children. Retrospective review of case records of 3 patients who were diagnosed to have idiopathic hypereosinophilic syndrome (IHES) in a tertiary referral centre between 1997 and 2010 was performed. These 3 children presented with different symptoms and the first case had cardiac involvement. All had very high absolute eosinophil count (cells/mm3) 43,206, 9,082, 2,925, respectively. Diagnosis was confirmed by bone marrow biopsy in all three cases and supported by liver biopsy in the first two cases and inguinal lymphnode biopsy in the last case. All 3 children responded to treatment with steroids, with only second patient requiring hydroxyurea to control disease. Case 1 and 2 are on follow up for 13 y and 10 y respectively and both are asymptomatic. Case 3 expired due to sepsis 1 mo after diagnosis. Treatment with steroids with or without hydroxyurea gave good response in all 3 cases. Hence, they still remain the gold standard for the treatment of IHES in children. |
| Databáze: | OpenAIRE |
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