Human textiles: A cell-synthesized yarn as a truly 'bio' material for tissue engineering applications

Autor: Nathalie Dusserre, Gaëlle Labrunie, Mickaël Lafourcade, Laure Magnan, Isabelle Svahn, Mathilde Fenelon, Todd N. McAllister, Nicolas L'Heureux, H V Jaime Vélez, Marie-Pierre Foulc, Etienne Gontier
Přispěvatelé: Bioingénierie tissulaire (BIOTIS), Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux (UB), RESCOLL (FRANCE), Bordeaux Imaging Center (BIC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut François Magendie-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Baxter/Renal Therapy Services, Fountain Therapeutics, Clinica Farallones Christus Sinergia - Baxter/Renal Therapy Services [Cali, Colombia] (CFCS), Fountain Therapeutics [Culver City, CA, USA] (FT), Chassande, Olivier, Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), L'Heureux, Nicolas
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Scaffold
Textile
Computer science
[SDV]Life Sciences [q-bio]
0206 medical engineering
Biomedical Engineering
Biocompatible Materials
Nanotechnology
02 engineering and technology
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Vascular graft
Biochemistry
Biomaterials
Rats
Nude
Tissue engineering
Mechanical strength
Animals
Humans
Weaving
[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
Molecular Biology
Engineered tissue
[SDV.IB] Life Sciences [q-bio]/Bioengineering
business.industry
Textiles
fungi
food and beverages
General Medicine
Yarn
Extracellular matrix
021001 nanoscience & nanotechnology
Human cells
020601 biomedical engineering
Blood Vessel Prosthesis
[SDV.IB.BIO] Life Sciences [q-bio]/Bioengineering/Biomaterials
[SDV] Life Sciences [q-bio]
visual_art
visual_art.visual_art_medium
[SDV.IB]Life Sciences [q-bio]/Bioengineering
0210 nano-technology
business
Burst pressure
Biotechnology
Zdroj: Acta Biomaterialia
Acta Biomaterialia, Elsevier, 2020, 105, pp.111-120. ⟨10.1016/j.actbio.2020.01.037⟩
Acta Biomaterialia, 2020, 105, pp.111-120. ⟨10.1016/j.actbio.2020.01.037⟩
ISSN: 1742-7061
Popis: International audience; In the field of tissue engineering, many groups have come to rely on the extracellular matrix produced by cells as the scaffold that provides structure and strength to the engineered tissue. We have previously shown that sheets of Cell-Assembled extracellular Matrix (CAM), which are entirely biological yet robust, can be mass-produced for clinical applications using normal, adult, human fibroblasts. In this article, we demonstrate that CAM yarns can be generated with a range of physical and mechanical properties. We show that this material can be used as a simple suture to close a wound or can be assembled into fully biological, human, tissue-engineered vascular grafts (TEVGs) that have high mechanical strength and are implantable. By combining this truly "bio" material with a textile-based assembly, this original tissue engineering approach is highly versatile and can produce a variety of strong human textiles that can be readily integrated in the body. STATEMENT OF SIGNIFICANCE: Yarn of synthetic biomaterials have been turned into textiles for decades because braiding, knitting and weaving machines can mass-produce medical devices with a wide range of shapes and mechanical properties. Here, we show that robust, completely biological, and human yarn can be produced by normal cells in vitro. This yarn can be used as a simple suture material or to produce the first human textiles. For example, we produced a woven tissue-engineered vascular grafts with burst pressure, suture retention strength and transmural permeability that surpassed clinical requirements. This novel strategy holds the promise of a next generation of medical textiles that will be mechanically strong without any foreign scaffolding, and will have the ability to truly integrate into the host's body.
Databáze: OpenAIRE
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