Further evidence of antigenic drift and protective efficacy afforded by a recombinant HVT-H5 vaccine against challenge with two antigenically divergent Egyptian clade 2.2.1 HPAI H5N1 strains

Autor:	V. Palya, Tímea Tatár-Kis, Sarah Welby, Mona M. Aly, S. Van Borm, Fabienne Rauw, K. Moore Dorsey, Mohamed K. Hassan, Yannick Gardin, Bénédicte Lambrecht, T. van den Berg, Mohamed A. Soliman
Rok vydání:	2011
Předmět:	animal diseases Genetic Vectors Orthomyxoviridae Immunization Secondary Hemagglutinin Glycoproteins Influenza Virus Biology Antibodies Viral medicine.disease_cause Antigenic drift Herpesvirus 1 Meleagrid parasitic diseases Influenza A virus medicine Animals Clade Drug Carriers Vaccines Synthetic Influenza A Virus H5N1 Subtype General Veterinary General Immunology and Microbiology Strain (biology) Vaccination Public Health Environmental and Occupational Health virus diseases Hemagglutination Inhibition Tests biology.organism_classification Virology humanities Influenza A virus subtype H5N1 Infectious Diseases Vaccines Inactivated Influenza Vaccines Influenza in Birds Inactivated vaccine Molecular Medicine Influenza A Virus H5N2 Subtype Chickens
Zdroj:	Vaccine. 29:2590-2600
ISSN:	0264-410X
DOI:	10.1016/j.vaccine.2011.01.048
Popis:	In this study, we have compared the protection afforded by a recombinant turkey herpesvirus vaccine expressing the H5 gene from a clade 2.2 H5N1 strain (rHVT-H5) and a Mexican-origin H5N2 inactivated vaccine, alone or in combination, against two antigenically divergent H5N1 Egyptian strains isolated in 2007 and 2008. Our results confirm the existence of a major antigenic drift among the Egyptian H5N1 strains such that, although protection against the "classical" 2007 HPAI H5N1 Egyptian strain could be obtained with both types of vaccines, only vaccination with the rHVT-H5 vaccine protected against challenge with the "variant" 2008 HPAI H5N1 Egyptian strain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf742e22120744bedf944eaa5ebf645c https://doi.org/10.1016/j.vaccine.2011.01.048 Zobrazit plný text záznamu Full Text from ScienceDirect