Stereotyped Relationship Between Motor and Cognitive Metabolic Networks in Parkinson's Disease

Autor: Tomaž Rus, Katharina A. Schindlbeck, Chris C. Tang, An Vo, Vijay Dhawan, Maja Trošt, David Eidelberg
Rok vydání: 2022
Předmět:
Zdroj: Movement Disorders. 37:2247-2256
ISSN: 1531-8257
0885-3185
DOI: 10.1002/mds.29188
Popis: Idiopathic Parkinson's disease (iPD) is associated with two distinct brain networks, PD-related pattern (PDRP) and PD-related cognitive pattern (PDCP), which correlate respectively with motor and cognitive symptoms. The relationship between the two networks in individual patients is unclear.To determine whether a consistent relationship exists between these networks, we measured the difference between PDRP and PDCP expression, termed delta, on an individual basis in independent populations of patients with iPD (n = 356), patients with idiopathic REM sleep behavioral disorder (iRBD) (n = 21), patients with genotypic PD (gPD) carrying GBA1 variants (n = 12) or the LRRK2-G2019S mutation (n = 14), patients with atypical parkinsonian syndromes (n = 238), and healthy control subjects (n = 95) from the United States, Slovenia, India, and South Korea.We used [Delta was abnormally elevated in each of the four iPD samples (P 0.05), as well as in the at-risk iRBD group (P 0.05), with increasing values over time (P 0.001). PDRP predominance was also present in gPD, with higher values in patients with GBA1 variants compared with the less aggressive LRRK2-G2019S mutation (P = 0.005). This trend was not observed in patients with atypical parkinsonian syndromes, who were accurately discriminated from iPD based on PDRP expression and delta (area under the curve = 0.85; P 0.0001).PDRP predominance, quantified by delta, assays the spread of dysfunction from motor to cognitive networks in patients with PD. Delta may therefore aid in differential diagnosis and in tracking disease progression in individual patients. © 2022 International Parkinson and Movement Disorder Society.
Databáze: OpenAIRE
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