Convergence of circuit dysfunction in ASD: a common bridge between diverse genetic and environmental risk factors and common clinical electrophysiology
| Autor: | Russell G Port, Michael J Gandal, Timothy eRoberts, Steven J Siegel, Greg C Carlson |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
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Context (language use) Review Article Electroencephalography ASD lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience VSDi 0302 clinical medicine medicine EEG education lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry 030304 developmental biology 0303 health sciences education.field_of_study MEG medicine.diagnostic_test Mechanism (biology) translational Cognition Neurophysiology medicine.disease Autism spectrum disorder Clinical electrophysiology gamma neurophysiology Psychology Neuroscience circuit 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Cellular Neuroscience Frontiers in Cellular Neuroscience, Vol 8 (2014) |
| ISSN: | 1662-5102 |
| Popis: | Most recent estimates indicate that 1 in 68 children are affected by an autism spectrum disorder (ASD). Though decades of research have uncovered much about these disorders, the pathological mechanism remains unknown. Hampering efforts is the seeming inability to integrate findings over the micro to macro scales of study, from changes in molecular, synaptic and cellular function to large-scale brain dysfunction impacting sensory, communicative, motor and cognitive activity. In this review, we describe how studies focusing on neuronal circuit function provide unique context for identifying common neurobiological disease mechanisms of ASD. We discuss how recent EEG and MEG studies in subjects with ASD have repeatedly shown alterations in ensemble population recordings (both in simple evoked related potential latencies and specific frequency subcomponents). Because these disease-associated electrophysiological abnormalities have been recapitulated in rodent models, studying circuit differences in these models may provide access to abnormal circuit function found in ASD. We then identify emerging in vivo and ex vivo techniques, focusing on how these assays can characterize circuit level dysfunction and determine if these abnormalities underlie abnormal clinical electrophysiology. Such circuit level study in animal models may help us understand how diverse genetic and environmental risks can produce a common set of EEG, MEG and anatomical abnormalities found in ASD. |
| Databáze: | OpenAIRE |
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