Hyperlipidemia in Early Adulthood Increases Long-Term Risk of Coronary Heart Disease
| Autor: | Allan D. Sniderman, Ann Marie Navar-Boggan, Benjamin Neely, Eric D. Peterson, Ralph B. D'Agostino, Michael J. Pencina |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Offspring Coronary Disease Hyperlipidemias Disease Cohort Studies chemistry.chemical_compound Risk Factors Physiology (medical) Internal medicine Hyperlipidemia medicine Humans Prospective Studies cardiovascular diseases Young adult Framingham Risk Score Cholesterol business.industry Middle Aged medicine.disease Endocrinology chemistry Cohort Female Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business Follow-Up Studies Lipoprotein |
| Zdroj: | Circulation. 131:451-458 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circulationaha.114.012477 |
| Popis: | Background— Many young adults with moderate hyperlipidemia do not meet statin treatment criteria under the new American Heart Association/American College of Cardiology cholesterol guidelines because they focus on 10-year cardiovascular risk. We evaluated the association between years of exposure to hypercholesterolemia in early adulthood and future coronary heart disease (CHD) risk. Methods and Results— We examined Framingham Offspring Cohort data to identify adults without incident cardiovascular disease to 55 years of age (n=1478), and explored the association between duration of moderate hyperlipidemia (non–high-density lipoprotein cholesterol≥160 mg/dL) in early adulthood and subsequent CHD. At median 15-year follow-up, CHD rates were significantly elevated among adults with prolonged hyperlipidemia exposure by 55 years of age: 4.4% for those with no exposure, 8.1% for those with 1 to 10 years of exposure, and 16.5% for those with 11 to 20 years of exposure ( P Conclusions— Cumulative exposure to hyperlipidemia in young adulthood increases the subsequent risk of CHD in a dose-dependent fashion. Adults with prolonged exposure to even moderate elevations in non–high-density lipoprotein cholesterol have elevated risk for future CHD and may benefit from more aggressive primary prevention. |
| Databáze: | OpenAIRE |
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