Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA

Autor:	Depei Wu, Xiaoyu Xu, Lijun Wen, Jinlan Pan, Zhao Zeng, Changgeng Ruan, Dewan Zhao, Zheng Wang, Li Yao, Man Wang, Jingzhi Shen, Jia Zhilin, Guangquan Mo, Xiaoqian Chen, Cai Wei, Yi Xu, Suning Chen, Ling Zhang, Wang Yao, Xiaomeng Chi, Zhen Shen
Rok vydání:	2020
Předmět:	0301 basic medicine Acute promyelocytic leukemia Male Cancer Research Oncogene Proteins Fusion Chromosomal translocation T-15 Biology Translocation Genetic Fusion gene 03 medical and health sciences 0302 clinical medicine Leukemia Promyelocytic Acute immune system diseases medicine Humans neoplasms Molecular Biology In Situ Hybridization Fluorescence Fusion Chromosomes Human Pair 15 Disease entity Gene Expression Regulation Leukemic Retinoic Acid Receptor alpha Intracellular Signaling Peptides and Proteins Myeloid leukemia Middle Aged medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Identification (biology) Chromosomes Human Pair 17
Zdroj:	Molecular carcinogenesisREFERENCES. 60(2)
ISSN:	1098-2744
Popis:	Acute promyelocytic leukemia (APL) is a unique disease entity in acute myeloid leukemia, characterized by PML-RARA fusion gene, which is generated by chromosomal translocation t(15;17)(q24;q21). We identified TNRC18-RARA as novel RARA fusion in resembling APL. Our study highlights the importance of combining multiple molecular techniques to characterize and optimally manage APL lacking classic t(15;17)(q24;q12)/PML-RARA fusion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7382b5de5077d8551462a6d1c97fb4 https://pubmed.ncbi.nlm.nih.gov/33428799 Zobrazit plný text záznamu Plný text