Allergen immunotherapy for insect venom allergy
| Autor: | Franziska Ruëff, Radosław Gawlik, Moises A. Calderon, Darío Antolín-Amérigo, Ewa Cichocka-Jarosz, Ervin Ç. Mingomataj, Markus Ollert, Danijela Bokanovic, Eva-Maria Varga, Joanna Lange, Hadar Zaman, Aziz Sheikh, M. B. Bilò, T. Jakob, V. Pravettoni, Miqdad Asaria, Graham Roberts, Oliver Pfaar, H. N. G. Oude Elberink, Constantinos Pitsios, G. Netuveli, Mitja Košnik, S. Dhami, Antonella Muraro, Holger Mosbech, Cezmi A. Akdis, Betül Ayşe Sin, Dimitris I. Mitsias, Gunter J. Sturm |
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| Přispěvatelé: | University of Zurich, Dhami, S |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
STINGS PROTOCOL Allergy Cost-Benefit Analysis CHILDREN law.invention DOUBLE-BLIND 0302 clinical medicine Randomized controlled trial law Risk Factors 10183 Swiss Institute of Allergy and Asthma Research Immunology and Allergy HYMENOPTERA VENOM systemic sting reaction Arthropod Venoms HYPERSENSITIVITY ANAPHYLAXIS Absolute risk reduction Disease Management LARGE LOCAL REACTIONS Treatment Outcome SUBLINGUAL IMMUNOTHERAPY Meta-analysis 2723 Immunology and Allergy Anaphylaxis Allergen immunotherapy medicine.medical_specialty Immunology 610 Medicine & health CONTROLLED-TRIAL 03 medical and health sciences hymenoptera venom allergy medicine Animals Humans Intensive care medicine Adverse effect 2403 Immunology business.industry Insect Bites and Stings Allergens medicine.disease Sting 030104 developmental biology 030228 respiratory system Desensitization Immunologic insect venom allergy business |
| Zdroj: | Dhami, S, Zaman, H, Varga, E-M, Sturm, G J, Muraro, A, Akdis, C A, Antolin-Amerigo, D, Bilò, M B, Bokanovic, D, Calderón, M A, Cichocka-Jarosz, E, Oude Elberink, J NG, Gawlik, R, Jakob, T, Kosnik, M, Lange, J, Mingomataj, E, Mitsias, D I, Mosbech, H, Ollert, M, Pfaar, O, Pitsios, C, Pravettoni, V, Roberts, G, Ruëff, F, Ayse Sin, B, Netuveli, G & Sheikh, A 2016, ' Allergen immunotherapy for insect venom allergy: a systematic review and meta-analysis ', Allergy . https://doi.org/10.1111/all.13077 |
| ISSN: | 0105-4538 1398-9995 |
| Popis: | Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines on Allergen Immunotherapy (AIT) for the management of insect venom allergy. To inform this process, we sought to assess the effectiveness, cost-effectiveness and safety of AIT in the management of insect venom allergy.Methods: We undertook a systematic review, which involved searching 15 international biomedical databases for published and unpublished evidence. Studies were independently screened and critically appraised using established instruments. Data were descriptively summarized and, where possible meta-analysed.Results: Our searches identified a total of 16,917 potentially eligible studies of which 17 satisfied our inclusion criteria. The available evidence was limited both in volume and quality, but suggested that venom immunotherapy (VIT) could substantially reduce the risk of subsequent severe systemic sting reactions (OR=0.08, 95% CI 0.03 to 0.26); meta-analysis showed that it also improved disease specific quality of life (risk difference=1.41, 95% CI 1.04 to 1.79). Adverse effects were experienced in both the build-up and maintenance phases, but most were mild with no fatalities being reported. The very limited evidence found on modeling cost-effectiveness suggested that VIT was likely to be cost-effective in those at high risk of repeated systemic sting reactions and/or impaired quality of life.Conclusions: The limited available evidence suggested that VIT is effective in reducing severe subsequent systemic sting reactions and in improving disease specific quality of life. VIT proved to be safe and no fatalities were recorded in the studies included in this review. The cost-effectiveness of VIT needs to be established. |
| Databáze: | OpenAIRE |
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