In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta
| Autor: | Ákos Csonka, Jan Oszmiański, Sylwia Cyboran-Mikołajczyk, Halina Kleszczyńska, Joseph Molnár, Diana Szabo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Nutrition and Dietetics Traditional medicine biology Chemistry lcsh:TX341-641 biology.organism_classification In vitro Multiple drug resistance 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Plant science Proanthocyanidin anti-hemolytic activity Actinidia arguta multidrug resistance 030220 oncology & carcinogenesis mini-kiwi (Actinidia arguta) Cytotoxic T cell lcsh:Nutrition. Foods and food supply Food Science cytotoxic activity L5178Y cells |
| Zdroj: | Polish Journal of Food and Nutrition Sciences, Vol 68, Iss 2, Pp 171-177 (2018) |
| ISSN: | 2083-6007 |
| Popis: | The leaves of mini kiwi (Actinidia arguta) are a rich source of phenolic compounds, in particular the B-type procyanidins that exhibit e.g. antioxidant, anticancer, antiviral, and anti-inflammatory activities. The aim of this study was to determine the biological activity of the extract from leaves of kiwi in relation to cells of erythrocytes and lymphoma. This activity was determined by studying kiwi leaves extract anti-hemolytic, cytotoxic and antiproliferative activity, and its ability to change the physical properties of the cell membrane and inhibit multidrug resistance of mouse lymphoma cells. It was shown that the extract ingredients bound to the cells, caused changes in erythrocyte shape and slightly affected the granularity and size of lymphoma cells. They effectively protected the red blood cells from oxidative damage, but were not toxic to lymphoma cells and did not affect their multidrug resistance. The extract of kiwi leaves is an effective antioxidant but it does not exhibit cytotoxic activity. Therefore, it can be used in the prevention of diseases, especially those related to oxidative stress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
http://www.degruyter.com/view/j/pjfns.2018.68.issue-2/pjfns-2017-0021/pjfns-2017-0021.xml?format=INT
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