Genetically modified cells in regenerative medicine and tissue engineering☆
| Autor: | Zulma Gazit, Olga Mizrahi, Dima Sheyn, Shimon Benjamin, Dan Gazit, Gadi Pelled |
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| Rok vydání: | 2010 |
| Předmět: |
Clinical Trials as Topic
Modern medicine New horizons Tissue Engineering Cell Transplantation Pharmaceutical Science Gene transfer Genetic Therapy Biology Regenerative Medicine Regenerative medicine Genetically modified organism Clinical Practice Tissue engineering Animals Humans Engineering ethics Genetic Engineering Cell aging Stem Cell Transplantation |
| Zdroj: | Advanced Drug Delivery Reviews. 62:683-698 |
| ISSN: | 0169-409X |
| DOI: | 10.1016/j.addr.2010.01.002 |
| Popis: | Regenerative medicine appears to take as its patron, the Titan Prometheus, whose liver was able to regenerate daily, as the field attempts to restore lost, damaged, or aging cells and tissues. The tremendous technological progress achieved during the last decade in gene transfer methods and imaging techniques, as well as recent increases in our knowledge of cell biology, have opened new horizons in the field of regenerative medicine. Genetically engineered cells are a tool for tissue engineering and regenerative medicine, albeit a tool whose development is fraught with difficulties. Gene-and-cell therapy offers solutions to severe problems faced by modern medicine, but several impediments obstruct the path of such treatments as they move from the laboratory toward the clinical setting. In this review we provide an overview of recent advances in the gene-and-cell therapy approach and discuss the main hurdles and bottlenecks of this approach on its path to clinical trials and prospective clinical practice. |
| Databáze: | OpenAIRE |
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