Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate
| Autor: | Lidija Barišić, Marina Miletić, Veronika Kovač, Ivana Kmetič, Teuta Murati |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Chemistry Stereochemistry ferrocene ferrocene-resveratrol conjugate hepatoblastoma normal ovary cells resveratrol General Chemistry Resveratrol Ferrocene Ferrocene-resveratrol conjugate Hepatoblastoma Normal ovary cells lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology lcsh:QD1-999 Cytotoxic T cell Conjugate |
| Zdroj: | Croatica Chemica Acta, Vol 89, Iss 3, Pp 339-343 (2016) Croatica Chemica Acta Volume 89 Issue 3 |
| ISSN: | 0011-1643 1334-417X |
| Popis: | The bioorganometallic III containing trimethylene chain between ferrocene and resveratrol (3,5,4'-trihydroxystilbene, RSV) moieties connected via ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (1H, 13C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The RSV and ferrocene-RSV conjugate III were screened in vitro for their inhibitory effects against proliferation of hepatoblastoma (Hep G2) cells by MTT assay. Also, possible cytotoxicity towards normal ovary cells (CHO-K1) was evaluated. The obtained data revealed profound effects in biological/cytotoxic activity of III vs. RSV in Hep G2 cell line. Lower cytotoxicity of III was observed in normal ovary cells as compared to hepatoblastoma cells. This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Databáze: | OpenAIRE |
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