Phase separation drives X-chromosome inactivation: a hypothesis
| Autor: | Gian Gaetano Tartaglia, Mitchell Guttman, Alexandros Armaos, Philip Avner, Christoph Neumayer, Andrea Cerase |
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| Rok vydání: | 2019 |
| Předmět: |
Plasma protein binding
X-inactivation 03 medical and health sciences 0302 clinical medicine Stress granule Theoretical Models impringing genetics X-chromosome inactivation X Chromosome Inactivation Structural Biology Humans Molecular Biology X chromosome 030304 developmental biology 0303 health sciences Chemistry RNA Models Theoretical Paraspeckles Chromatin Cell biology Long Noncoding RNA Long Noncoding XIST Protein Binding 030217 neurology & neurosurgery |
| Zdroj: | Nature Structural & Molecular Biology. 26:331-334 |
| ISSN: | 1545-9985 1545-9993 |
| DOI: | 10.1038/s41594-019-0223-0 |
| Popis: | The long non-coding RNA Xist induces heterochromatinization of the X chromosome by recruiting repressive protein complexes to chromatin. Here we gather evidence, from the literature and from computational analyses, showing that Xist assemblies are similar in size, shape and composition to phase-separated condensates, such as paraspeckles and stress granules. Given the progressive sequestration of Xist’s binding partners during X-chromosome inactivation, we formulate the hypothesis that Xist uses phase separation to perform its function. |
| Databáze: | OpenAIRE |
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