Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants
| Autor: | Shinya Oue, Masako Yasui, Tohru Ogihara, Tadashi Inatomi, Masashi Hasegawa, Seigo Hira, Hiroshi Tamai, Shigeo Yamaoka |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment urologic and male genital diseases Ureaplasma Pregnancy Risk Factors medicine Humans Bronchopulmonary Dysplasia Retrospective Studies Mechanical ventilation biology business.industry Obstetrics Ureaplasma Infections Ureaplasma infection Mucin-1 Infant Newborn Recem nascido Retrospective cohort study Fetal Blood medicine.disease biology.organism_classification Respiration Artificial Body Fluids Surgery Logistic Models Bronchopulmonary dysplasia Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Ureaplasma species Female business Biomarkers Infant Premature |
| Zdroj: | Pediatric Research. 71:267-273 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1038/pr.2011.47 |
| Popis: | The presence of microorganisms in gastric fluid in neonates at birth is postulated to reflect antenatal infection and also to be associated with the development of bronchopulmonary dysplasia (BPD).A logistic regression analysis, after controlling for other risk factors, indicated that Ureaplasma-positive infants were not at increased risk for moderate/severe BPD (adjusted odds ratio (OR): 2.58, 95% confidence interval (CI): 0.57-6.89, P = 0.12). However, the association between the presence of Ureaplasma species and the risk for moderate/severe BPD increased significantly in infants on mechanical ventilation (MV) ≥2 wk (adjusted OR: 4.17, 95% CI: 1.62-44.1, P = 0.009). An analysis using a lung injury marker indicated that Ureaplasma-positive infants with MV ≥2 wk, but not other infants, showed higher serum KL-6 levels in samples taken from cord blood, and that KL-6 levels increased time-dependently up to 4 wk of age.Antenatal exposure to Ureaplasma species induces lung injury prior to birth and synergistically contributes to the development of BPD in infants requiring prolonged MV (≥2 wk).We recovered gastric fluid specimens from 122 infants with gestational age (GA)29 wk or birth weight1,000 g to investigate whether these microorganisms influence respiratory outcome of BPD. A PCR analysis was used to detect urease and 16S ribosomal RNA (rRNA) genes to classify neonates into Ureaplasma-positive or Ureaplasma-negative infants. |
| Databáze: | OpenAIRE |
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