Prognosis in Head and Neck Cancer: Importance of Nutritional and Biological Inflammatory Status

Autor: Céline Lambert, Maureen Bernadach, Michel Lapeyre, Laurent Gilain, Julian Biau, Thierry Mom, M Puechmaille, Achraf Sayed Hassan, Nicolas Saroul
Přispěvatelé: Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER
Rok vydání: 2021
Předmět:
MESH: Inflammation
Male
Neutrophils
[SDV]Life Sciences [q-bio]
MESH: Neutrophils
MESH: Monocytes
Monocytes
0302 clinical medicine
MESH: Social Status
030223 otorhinolaryngology
Head and neck
2. Zero hunger
MESH: Aged
MESH: Middle Aged
EPICES
Nutritional status
Middle Aged
MESH: Nutritional Status
Prognosis
TNM classification
3. Good health
Survival Rate
Social deprivation
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Female
Social status
medicine.medical_specialty
MESH: Lymphocyte Count
MESH: Survival Rate
Nutritional Status
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH: Prognosis
03 medical and health sciences
Internal medicine
medicine
Humans
MESH: Platelet Count
Lymphocyte Count
Aged
Retrospective Studies
Inflammation
MESH: Humans
business.industry
Platelet Count
Head and neck cancer
Retrospective cohort study
MESH: Retrospective Studies
Social Status
medicine.disease
SIRI
MESH: Male
social deprivation
MESH: Head and Neck Neoplasms
Otorhinolaryngology
NRI
Surgery
head and neck cancer
business
prognostic
MESH: Female
Zdroj: Archives of Otolaryngology Head and Neck Surgery
Archives of Otolaryngology Head and Neck Surgery, 2022, 166 (1), pp.118-127. ⟨10.1177/01945998211004592⟩
Archives of Otolaryngology Head and Neck Surgery, American Medical Association, In press, pp.019459982110045. ⟨10.1177/01945998211004592⟩
ISSN: 1097-6817
0886-4470
Popis: International audience; Objectives To determine the importance of nutritional status, social status, and inflammatory status in the prognosis of head and neck cancer. Study Design Single-center retrospective study of prospectively collected data. Setting Tertiary referral center. Methods Ninety-two consecutive patients newly diagnosed for cancer of the upper aerodigestive tract without metastases were assessed at time of diagnosis for several prognostic factors. Nutritional status was assessed by the nutritional risk index, social status by the EPICES score, and inflammatory status by the systemic inflammatory response index. The primary endpoint was overall survival. Results In multivariable analysis, the main prognostic factors were the TNM classification (hazard ratio [HR] = 3.34, P = .002, for stage T3-4), malnutrition as assessed by the nutritional risk index (HR = 3.64, P = .008, for severe malnutrition), and a systemic inflammatory response index score ≥1.6 (HR = 3.32, P = .02). Social deprivation was not a prognostic factor. Conclusion Prognosis in head and neck cancer is multifactorial; however, malnutrition and inflammation are important factors that are potentially reversible by early intervention.; Tertiary referral center.
Databáze: OpenAIRE
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