Clearance of technetium-99m-DTPA and HRCT findings in the evaluation of patients with Idiopathic Pulmonary Fibrosis
| Autor: | Demosthenes Bouros, Emmanouil K. Symvoulakis, Nikolaos Karkavitsas, Katerina Malagari, Nikolaos Siafakas, Katerina M. Antoniou, Nikolaos Tzanakis, Kostas Perisinakis |
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| Jazyk: | angličtina |
| Předmět: |
Male
Pulmonary and Respiratory Medicine High-resolution computed tomography Pathology medicine.medical_specialty Pulmonary Fibrosis Bronchoalveolar Lavage Severity of Illness Index Pulmonary function testing Epithelial Damage Idiopathic pulmonary fibrosis Predictive Value of Tests Pulmonary fibrosis medicine Humans Prospective Studies Aged lcsh:RC705-779 Aged 80 and over Lung medicine.diagnostic_test business.industry Cell Differentiation lcsh:Diseases of the respiratory system Middle Aged respiratory system medicine.disease Respiratory Function Tests respiratory tract diseases Bronchoalveolar lavage medicine.anatomical_structure Technetium Tc 99m Pentetate Female Radiopharmaceuticals business Tomography X-Ray Computed Technetium-99m Research Article |
| Zdroj: | BMC Pulmonary Medicine BMC Pulmonary Medicine, Vol 6, Iss 1, p 4 (2006) |
| ISSN: | 1471-2466 |
| DOI: | 10.1186/1471-2466-6-4 |
| Popis: | BackgroundClearance of inhaled technetium-labeled diethylenetriamine pentaacetate (99mTc-DTPA) is a marker of epithelial damage and an index of lung epithelial permeability. The aim of this study was to investigate the role of99mTc-DTPA scan in patients with Idiopathic Pulmonary Fibrosis (IPF). Our hypothesis is that the rate of pulmonary99mTc-DTPA clearance could be associated with extent of High Resolution Computed Tomography (HRCT) abnormalities, cell differential of bronchoalveolar lavage fluid (BALF) and pulmonary function tests (PFTs) in patients with IPF.MethodsWe studied prospectively 18 patients (14 male, 4 female) of median age 67yr (range 55–81) with histologically proven IPF. HRCT scoring included the mean values of extent of disease. Mean values of these percentages represented the Total Interstitial Disease Score (TID). DTPA clearance was analyzed according to a dynamic study using a Venticis II radioaerosol delivery system.ResultsThe mean (SD) TID score was 36 ± 12%, 3 patients had mild, 11 moderate and 4 severe TID. Abnormal DTPA clearance half-time (t1/2ConclusionOur data suggest that99mTc-DTPA lung scan is not well associated with HRCT abnormalities, PFTs, and BALF cellularity in patients with IPF. Further studies in large scale of patients are needed to define the role of this technique in pulmonary fibrosis. |
| Databáze: | OpenAIRE |
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