C-reactive protein in traditional melanesians on Kitava
| Autor: | Tommy Jönsson, Ulf Lindblad, Frits A. J. Muskiet, Maelán Fontes-Villalba, Pedro Carrera-Bastos, Yinon Shapira, Torbjörn Åkerfeldt, Yvonne Granfeldt, Michael Gurven, Yehuda Shoenfeld, Lennart Råstam, Kristina Sundquist, Johan Frostegård |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
lcsh:Diseases of the circulatory (Cardiovascular) system Type 2 diabetes 030204 cardiovascular system & hematology ISCHEMIC-HEART-DISEASE Systemic inflammation chemistry.chemical_compound 0302 clinical medicine MARKERS CARDIOVASCULAR RISK-FACTORS LOW-GRADE INFLAMMATION SKARABORG HYPERTENSION Aged 80 and over 0303 health sciences education.field_of_study biology Clinical Laboratory Medicine Middle Aged INSULIN Klinisk laboratoriemedicin Female Traditional melanesians FATTY-ACIDS Inflammation Mediators medicine.symptom Cardiology and Cardiovascular Medicine Research Article Adult medicine.medical_specialty PACIFIC ISLANDERS Population Down-Regulation Horticulture C-reactive protein Papua New Guinea 03 medical and health sciences Internal medicine medicine Humans Occupations education Aged 030304 developmental biology Inflammation business.industry Cholesterol DIABETES-MELLITUS medicine.disease Cardiovascular risk Endocrinology chemistry lcsh:RC666-701 Case-Control Studies Chronic Disease ANTIBODIES biology.protein Metabolic syndrome business Body mass index Biomarkers Lipoprotein |
| Zdroj: | BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-8 (2020) BMC Cardiovascular Disorders Bmc cardiovascular disorders, 20(1):524, 1-8. BioMed Central Ltd. |
| ISSN: | 1471-2261 |
| Popis: | Background Population-based levels of the chronic low-grade systemic inflammation biomarker, C-reactive protein (CRP), vary widely among traditional populations, despite their apparent absence of chronic conditions associated with chronic low-grade systemic inflammation, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. We have previously reported an apparent absence of aforementioned conditions amongst the traditional Melanesian horticulturalists of Kitava, Trobriand Islands, Papua New Guinea. Our objective in this study was to clarify associations between chronic low-grade systemic inflammation and chronic cardiometabolic conditions by measuring CRP in a Kitava population sample. For comparison purposes, CRP was also measured in Swedish controls matched for age and gender. Methods Fasting levels of serum CRP were measured cross-sectionally in ≥ 40-year-old Kitavans (N = 79) and Swedish controls (N = 83). Results CRP was lower for Kitavans compared to Swedish controls (Mdn 0.5 mg/L range 0.1—48 mg/L and Mdn 1.1 mg/L range 0.1—33 mg/L, respectively, r = .18 p = .02). Among Kitavans, there were small negative associations between lnCRP for CRP values Conclusions Chronic low-grade systemic inflammation, measured as CRP, was lower among Kitavans compared to Swedish controls, indicating a lower and average cardiovascular risk, respectively, for these populations. |
| Databáze: | OpenAIRE |
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