Laminar Organization of Working Memory Signals in Human Visual Cortex
| Autor: | David G. Norris, Floris P. de Lange, Peter J. Koopmans, Samuel J. D. Lawrence, Tim van Mourik, Peter Kok |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male genetic structures Computer science media_common.quotation_subject Medizin Sensory system Stimulus (physiology) Biology General Biochemistry Genetics and Molecular Biology 150 000 MR Techniques in Brain Function 03 medical and health sciences Laminar organization Young Adult 0302 clinical medicine Perception medicine Humans media_common Visual Cortex Working memory Action intention and motor control Perception Action and Control [DI-BCB_DCC_Theme 2] Cognition Laminar flow 180 000 Predictive Brain Middle Aged Magnetic Resonance Imaging eye diseases 030104 developmental biology medicine.anatomical_structure Visual cortex Memory Short-Term Human visual system model Female General Agricultural and Biological Sciences Cortical column Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Biology Current Biology, 28, 21, pp. 3435-3440.e4 Current Biology, 28, 3435-3440.e4 |
| ISSN: | 0960-9822 |
| Popis: | Contains fulltext : 197446.pdf (Publisher’s version ) (Closed access) The human primary visual cortex (V1) is not only activated by incoming visual information but is also engaged by top-down cognitive processes, such as visual working memory, even in the absence of visual input [1-3]. This feedback may be critical to our ability to visualize specific visual features, as higher-order regions lack the selectivity to represent such information [4]. Clearly, such internally generated signals do not trigger genuine perception of the remembered stimulus, meaning they must be organized in a manner that is different to bottom-up-driven signals. Internally generated signals may be kept separate from incoming sensory data by virtue of the laminar organization of inter-area cortical connections. Namely, bottom-up driving connections target layer 4, located in the middle of the cortical column, and feedback connections target deep and superficial layers and avoid layer 4 [5-7]. Using lamina-resolved fMRI, we simultaneously measured the activity in three early visual cortical areas (V1-V3) that are recruited to represent stimulus information during visual working memory [8]. We observed item-specific working memory signals in early visual cortex. In V1, this item-specific activity was selectively present at deep and superficial cortical depths, avoiding the middle layers, and working-memory-related activity was present at all depths in V2 and V3. These results show for the first time the laminar organization of internally generated signals during visual working memory in the human visual system and provide new insights into how bottom-up and top-down signals in visual cortex are deployed. 10 p. |
| Databáze: | OpenAIRE |
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