On the potential role of DNMT1 in acute myeloid leukemia and myelodysplastic syndromes: not another mutated epigenetic driver
| Autor: | Georgios Vartholomatos, Leonidas Benetatos |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
DNA (Cytosine-5-)-Methyltransferase 1
0301 basic medicine Methyltransferase Transcription Genetic DNMT3B Biology environment and public health DNA Methyltransferase 3A 03 medical and health sciences hemic and lymphatic diseases medicine Humans DNA (Cytosine-5-)-Methyltransferases Epigenetics Gene Expression Regulation Leukemic urogenital system Myelodysplastic syndromes Myeloid leukemia Hematopoietic stem cell Cell Differentiation DNA Neoplasm Hematology General Medicine DNA Methylation Hematopoietic Stem Cells medicine.disease Hematopoiesis Neoplasm Proteins Leukemia Myeloid Acute Haematopoiesis 030104 developmental biology medicine.anatomical_structure Myelodysplastic Syndromes embryonic structures DNA methylation Neoplastic Stem Cells Cancer research Transcription Factors |
| Zdroj: | Annals of Hematology. 95:1571-1582 |
| ISSN: | 1432-0584 0939-5555 |
| DOI: | 10.1007/s00277-016-2636-8 |
| Popis: | DNA methylation is the most common epigenetic modification in the mammalian genome. DNA methylation is governed by the DNA methyltransferases mainly DNMT1, DNMT3A, and DNMT3B. DNMT1 methylates hemimethylated DNA ensuring accurate DNA methylation maintenance. DNMT1 is involved in the proper differentiation of hematopoietic stem cells (HSCs) through the interaction with effector molecules. DNMT1 is deregulated in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) as early as the leukemic stem cell stage. Through the interaction with fundamental transcription factors, non-coding RNAs, fusion oncogenes and by modulating core members of signaling pathways, it can affect leukemic cells biology. DNMT1 action might be also catalytic-independent highlighting a methylation-independent mode of action. In this review, we have gathered some current facts of DNMT1 role in AML and MDS and we also propose some perspectives for future studies. |
| Databáze: | OpenAIRE |
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