Esophageal Dysfunction in Friesian Horses: Morphological Features
| Autor: | T Picavet, Bart J. Ducro, Andrea Gröne, Willem Back, M. Ploeg, C. M. de Bruijn, Veronique Saey, W Scheideman, Catherine Delesalle, P. R. van Weeren, Inge D. Wijnberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
collagen Pathology medicine.medical_specialty muscle esophageal muscular hypertrophy Biology Animal Breeding and Genomics Muscle hypertrophy histology symbols.namesake megaesophagus medicine Animals Fokkerij en Genomica Horses Esophagus equine esophagus General Veterinary Horse Megaesophagus Histology Hypertrophy medicine.disease Immunohistochemistry Breed Interstitial cell of Cajal Friesian Esophageal Achalasia Phenotype medicine.anatomical_structure symbols WIAS Female Horse Diseases Tunica |
| Zdroj: | Veterinary Pathology, 52(6), 1142-1147 Veterinary Pathology 52 (2015) 6 |
| ISSN: | 0300-9858 |
| DOI: | 10.1177/0300985814556780 |
| Popis: | Megaesophagus appears to be more common in Friesian horses than in other breeds. A prevalence of approximately 2% was observed among Friesian horses presented to the Wolvega Equine Clinic and the Utrecht University Equine Clinic. In this study, morphologic changes in the esophagi of Friesian horses with megaesophagus were compared with those of 6 control horses. Of 18 horses with clinically observed megaesophagus, only 12 animals had esophageal dilation at necropsy, usually involving the thoracic portion. Muscular hypertrophy of the distal esophagus was present in only one-third of the affected horses, indicating that this change is not the most relevant cause of megaesophagus in Friesians. Increased deposition of clumped and disorganized collagen was present in these clinically affected horses mainly in the non-dilated portion of the esophagus. At necropsy, a decrease in neural elements and elastin was present principally in horses with megaesophagus. Mild degeneration and necrosis of the tunica muscularis along the entire length of the esophagus were present in clinically affected horses and encountered only rarely in control animals. There were no significant differences among affected and control horses with respect to inflammation, mineralization, or the number of cells of Cajal. The increased occurrence of megaesophagus in the Friesian breed compared with other horse breeds, together with the presence of abnormal collagen in very young foals, supports the hypothesis that megaesophagus is hereditary in Friesians. |
| Databáze: | OpenAIRE |
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