Clinical significance of Ki-67, c-erbB-2 and E-cadherin expressions in open partial laryngectomy patients
| Autor: | Sefa Derekoy, Ozan Barutçu, Oğuz Güçlü, Asli Muratli, Medine Kara |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty C erbb 2 Proliferation index Receptor ErbB-2 Laryngectomy Stain 03 medical and health sciences 0302 clinical medicine Antigens CD Internal medicine Biomarkers Tumor medicine Humans Clinical significance 030223 otorhinolaryngology Laryngeal Neoplasms Lymph node Partial laryngectomy Aged biology business.industry Cadherin General Medicine Middle Aged Cadherins Prognosis Immunohistochemistry Ki-67 Antigen medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis Ki-67 biology.protein Female Lymph Nodes Neoplasm Recurrence Local business |
| Zdroj: | The Turkish Journal of Ear Nose and Throat. 26:283-292 |
| ISSN: | 2147-6756 1300-7475 |
| Popis: | OBJECTIVES This study aims to analyze the correlation between biomarkers and risks of cervical lymph node invasion, recurrence, distant metastasis and survival regarding the clinicopathological variables in laryngeal cancers. PATIENTS AND METHODS Forty-one patients with laryngeal cancers were examined retrospectively. The correlations evaluated between E-cadherin, Ki-67, c-erbB-2 expressions, tumor site, differentiation, the risk of cervical lymph node metastasis, perineural, perivascular, pericapsular invasion and recurrence as well as survival time. RESULTS There was significant correlation between T-grade and the survival rates, and between pericapsular invasion and the lowest survival rates. There was no significant correlation between E-cadherin, Ki-67, c-erbB-2 expressions and clinicopathological variables of tumor. Positive correlation between strong stain of E-cadherin and Ki-67 proliferation index was determined. CONCLUSION These markers are not reliable prognostic and predictive factors for laryngeal cancers. E-cadherin expression was protected in well-differentiated and less invasive cancers, which maintain their cell-cell adhesions whereas it was reduced in undifferentiated cancers. Positive correlation between E-cadherin and Ki-67 proliferation shows that histopathological differentiation of laryngeal cancers is maintained in spite of the high proliferation index. |
| Databáze: | OpenAIRE |
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