Pseudothrombocytopenia Due to Platelet Aggregation and Degranulation in Blood Collected in EDTA
| Autor: | M. J. Mant, J. Gauldie, James C.G. Doery, H. Sims |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Blood Platelets Male Time Factors Adolescent Platelet Aggregation Fibrinogen Abnormal platelet morphology Adenosine Triphosphate medicine Humans Platelet Edetic Acid Aged Blood Specimen Collection L-Lactate Dehydrogenase Chemistry Degranulation Albumin Anticoagulants Hematology Heparin Thrombocytopenia Cold Agglutinin Blood Cell Count Adenosine Diphosphate Pseudothrombocytopenia Immunology Female Blood Coagulation Tests medicine.drug |
| Zdroj: | Scandinavian Journal of Haematology. 15:161-170 |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1975.tb01070.x |
| Popis: | Three patients are described in whom platelet aggregation and/or degranulation occurred in blood collected into EDTA. These changes resulted in spurious thrombocytopenia and morphological changes similar to those observed in some thrombocytopathies. The abnormalities were dependent on the presence of EDTA and did not occur in citrate, oxalate or heparin anticoagulants. In two patients the abnormality was shown to be due to a plasma factor which was not IgG, IgM, fibrinogen or albumin. The most likely explanation is that these patients have an unidentified abnormal plasma component which, on exposure to EDTA, develops 'anti-platelet activity'. Althought relatively uncommon a prospective study of the incidence of these phenomena indicates that they are probably more common than either platelet cold agglutinins or platelet satellitism. They have practical significance with respect to the diagnosis of thrombocytopenia and also to the interpretation of abnormal platelet morphology. |
| Databáze: | OpenAIRE |
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