SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer
| Autor: | Amanda H. Seipel, Amilcar Flores-Morales, Daniela Danneman, Leandro Fernández-Pérez, Yuanjie Niu, Ning Jiang, Gunnar Norstedt, Lars Egevad, Marcel Vermeij, Sandra Augsten, Diego Iglesias-Gato, Guido Jenster, Pernilla Wikström, Yin Choy Chuan |
|---|---|
| Přispěvatelé: | Pathology, Urology |
| Rok vydání: | 2014 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.drug_class medicine.medical_treatment Suppressor of Cytokine Signaling Proteins Adenocarcinoma Prostate cancer SDG 3 - Good Health and Well-being Prostate Predictive Value of Tests Internal medicine Cell Line Tumor medicine STAT5 Transcription Factor Animals Humans Insulin-Like Growth Factor I P-Chloroamphetamine SOCS2 Aged Cell Proliferation business.industry Human Growth Hormone Growth factor Prostatic Neoplasms General Medicine Metribolone Middle Aged medicine.disease Androgen Mice Mutant Strains Mice Inbred C57BL Somatropin Prostatic Neoplasms Castration-Resistant medicine.anatomical_structure Endocrinology Receptors Androgen Androgens business Hormone Signal Transduction |
| Zdroj: | Carcinogenesis, 35(1), 24-33. Oxford University Press |
| ISSN: | 0143-3334 |
| Popis: | Anabolic signals such as androgens and the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis play an essential role in the normal development of the prostate but also in its malignant transformation. In this study, we investigated the role of suppressor of cytokine signaling 2 (SOCS2) as mediator of the cross talk between androgens and GH signals in the prostate and its potential role as tumor suppressor in prostate cancer (PCa). We observed that SOCS2 protein levels assayed by immunohistochemistry are elevated in hormone therapy-naive localized prostatic adenocarcinoma in comparison with benign tissue. In contrast, however, castration-resistant bone metastases exhibit reduced levels of SOCS2 in comparison with localized or hormone naive, untreated metastatic tumors. In PCa cells, SOCS2 expression is induced by androgens through a mechanism that requires signal transducer and activator of transcription 5 protein (STAT5) and androgen receptor-dependent transcription. Consequentially, SOCS2 inhibits GH activation of Janus kinase 2, Src and STAT5 as well as both cell invasion and cell proliferation in vitro. In vivo, SOCS2 limits proliferation and production of IGF-1 in the prostate in response to GH. Our results suggest that the use of GH-signaling inhibitors could be of value as a complementary treatment for castration-resistant PCa. Summary: Androgen induced SOCS2 ubiquitin ligase expression and inhibited GH signaling as well as cell proliferation and invasion in PCa, whereas reduced SOCS2 was present in castration-resistant cases. GH-signaling inhibitors might be a complementary therapeutic option for advanced PCa. |
| Databáze: | OpenAIRE |
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