Drug-Supported Microparticles of Calcium Carbonate Nanocrystals and Its Covering with Hydroxyapatite
| Autor: | Junzo Tanaka, Yutaka Mizushima, Hajime Watanaba, Toru Tonegawa, Guoping Chen, Toshiyuki Ikoma |
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| Rok vydání: | 2007 |
| Předmět: |
Materials science
Hydrocortisone Biomedical Engineering Bioengineering Crystal growth Calcium Carbonate chemistry.chemical_compound Drug Delivery Systems Adsorption X-Ray Diffraction Vaterite Spectroscopy Fourier Transform Infrared Nanotechnology General Materials Science Particle Size Magnesium ion Calcite Supersaturation General Chemistry Condensed Matter Physics Phosphate Microscopy Electron Durapatite Calcium carbonate chemistry Chemical engineering Microscopy Electron Scanning Nanoparticles |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 7:822-827 |
| ISSN: | 1533-4880 |
| Popis: | Drug-supported spherical microparticles with below 3 microm in diameter of calcium carbonate (CC) nanocrystals were precipitated by a complex decomposition method from Na2CO3 and CaCl2 solutions with hydrocortisone phosphate (HyC). The HyC was completely incorporated into the microparticles and was adsorbed on the surface of nanocrystals. The crystal phases of vaterite and calcite were controlled by the addition of magnesium ions. Spherical microparticles of calcite cores and petal-shaped hydroxyapatite (HAp) outer layers were fabricated by soaking calcite into the SBF, or a supersaturated solution of phosphate ions to enhance the crystal growth of HAp. |
| Databáze: | OpenAIRE |
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