Molecular Mechanisms and Biological Functions of Autophagy for Genetics of Hearing Impairment
| Autor: | Chisato Fujimoto, Yuna Suzuki, Ken Hayashi, Sho Kanzaki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Programmed cell death lcsh:QH426-470 Hearing loss Necroptosis Apoptosis Review Cell fate determination 03 medical and health sciences 0302 clinical medicine Hearing Hair Cells Auditory Autophagy Genetics medicine otorhinolaryngologic diseases Humans Hearing Loss Genetics (clinical) Spiral ganglion Neurons Cell Death congenital disorder business.industry medicine.disease lcsh:Genetics 030104 developmental biology medicine.anatomical_structure autophagy- and lysosomal function-related genes Ear Inner classical degradative autophagy Sensorineural hearing loss sense organs medicine.symptom Spiral Ganglion business Neuroscience 030217 neurology & neurosurgery Intracellular genetics of hearing impairment |
| Zdroj: | Genes, Vol 11, Iss 1331, p 1331 (2020) Genes |
| ISSN: | 2073-4425 |
| Popis: | The etiology of hearing impairment following cochlear damage can be caused by many factors, including congenital or acquired onset, ototoxic drugs, noise exposure, and aging. Regardless of the many different etiologies, a common pathologic change is auditory cell death. It may be difficult to explain hearing impairment only from the aspect of cell death including apoptosis, necrosis, or necroptosis because the level of hearing loss varies widely. Therefore, we focused on autophagy as an intracellular phenomenon functionally competing with cell death. Autophagy is a dynamic lysosomal degradation and recycling system in the eukaryotic cell, mandatory for controlling the balance between cell survival and cell death induced by cellular stress, and maintaining homeostasis of postmitotic cells, including hair cells (HCs) and spiral ganglion neurons (SGNs) in the inner ear. Autophagy is considered a candidate for the auditory cell fate decision factor, whereas autophagy deficiency could be one of major causes of hearing impairment. In this paper, we review the molecular mechanisms and biologic functions of autophagy in the auditory system and discuss the latest research concerning autophagy-related genes and sensorineural hearing loss to gain insight into the role of autophagic mechanisms in inner-ear disorders. |
| Databáze: | OpenAIRE |
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