Psychopathological and SPECT findings in never-treated schizophrenia
| Autor: | Osama Sabri, H. Saß, R. Erkwoh, Udalrich Büll, E.-M. Steinmeyer |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Reality Testing Hypofrontality Gyrus Cinguli Internal medicine Limbic System medicine Humans Longitudinal Studies Psychiatry Anterior cingulate cortex Aged Aged 80 and over Cerebral Cortex Tomography Emission-Computed Single-Photon Positive and Negative Syndrome Scale Middle Aged medicine.disease Temporal Lobe Frontal Lobe Psychiatry and Mental health Cross-Sectional Studies Treatment Outcome medicine.anatomical_structure Cerebral blood flow Schizophrenia Case-Control Studies Cerebrovascular Circulation Cardiology Female Schizophrenic Psychology Factor Analysis Statistical Psychology Perfusion Antipsychotic Agents Psychopathology |
| Zdroj: | Acta Psychiatrica Scandinavica. 96:51-57 |
| ISSN: | 1600-0447 0001-690X |
| DOI: | 10.1111/j.1600-0447.1997.tb09904.x |
| Popis: | A total of 24 never-treated (i.e. drug-naive) actively psychotic schizophrenic patients, operationalized according to DSM-III-R, were examined in a pre-post-treatment design using the Positive and Negative Syndrome Scale for Schizophrenia (PANSS) and 99mTc-HMPAO-single photon emission computed tomography (SPECT) to assess regional cerebral blood flow (rCBF). The control subjects were 20 patients free of neurological and psychiatric symptoms. Before treatment there was only a slight hypofrontality, and hypoperfusion was observed in the left temporal superior region. After treatment, hypofrontality was reduced to one region and temporal hypoperfusion disappeared. Formal thought disorders were accompanied by increased rCBF in the bilateral frontal interior and left temporal superior regions. Delusions were associated with hypoperfusion in the anterior cingulate cortex. Negative symptoms showed no linkage to hypofrontality, either before or after treatment. Factor analysis showed delusions and hallucinations loading on different dimensions. The disorganized dimension correlated positively with all regions of interest, whereas these were negatively correlated with reality distortion. |
| Databáze: | OpenAIRE |
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