Norms for Clinical Use of CXM, a Real-Time Marker of Height Velocity

Autor: Robert C. Olney, William A. Horton, Ryan F. Coghlan, Bruce A. Boston, Brian Johnstone, Daniel Coleman
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Future studies
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Biochemistry
Time marker
type X collagen
Preliminary analysis
Correlation
Child Development
0302 clinical medicine
Endocrinology
Reference Values
Growth Charts
Practice Patterns
Physicians'
Child
Bone growth
Reference Standards
Dried blood spot
height velocity
Current practice
Child
Preschool
biomarker
Female
AcademicSubjects/MED00250
medicine.medical_specialty
Adolescent
growth
030209 endocrinology & metabolism
Context (language use)
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
Online Only Articles
Clinical Research Articles
Bone Development
bone growth
business.industry
Biochemistry (medical)
Infant
CXM
Body Height
United States
030104 developmental biology
business
Nuclear medicine
Biomarkers
Collagen Type X
Zdroj: The Journal of Clinical Endocrinology and Metabolism
ISSN: 1945-7197
0021-972X
DOI: 10.1210/clinem/dgaa721
Popis: Context Height velocity (HV) is difficult to assess because growth is very slow. The current practice of calculating it from measurements taken at several-month intervals is insufficient for managing children with growth disorders. We identified a bone growth by-product (collagen X biomarker, CXM) in blood that in preliminary analysis in healthy children correlated strongly with conventionally determined HV and displayed a pattern resembling published norms for HV vs age. Objective The goal was to confirm our initial observations supporting the utility of CXM as an HV biomarker in a larger number of individuals and establish working reference ranges for future studies. Design, Settings, and Participants CXM was assessed in archived blood samples from 302 healthy children and 10 healthy adults yielding 961 CXM measurements. A total of 432 measurements were plotted by age, and sex-specific reference ranges were calculated. Serial values from 116 participants were plotted against observed HV. Matched plasma, serum, and dried blood spot readings were compared. Results A correlation of blood CXM with conventional HV was confirmed. Scatter plots of CXM vs age showed a similar pattern to current HV norms, and CXM levels demarcated the pubertal growth spurt both in girls and boys. CXM levels differed little in matched serum, plasma, and dried blood spot samples. Conclusions Blood CXM offers a potential means to estimate HV in real time. Our results establish sex-specific, working reference ranges for assessing skeletal growth, especially over time. CXM stability in stored samples makes it well suited for retrospective studies.
Databáze: OpenAIRE
Externí odkaz: