Heparin Neutralization by an Extract of the Human Placenta: Measurements and the Concept of Placental Barrier to Heparin
| Autor: | Mieczysław Uszynski |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.drug_class
Drug Evaluation Preclinical Pharmacology Biology Placental barrier Chromatography Affinity Neutralization Pharmacokinetics Pregnancy In vivo Placenta medicine Humans Placental Extracts Drug Interactions Maternal-Fetal Exchange Heparin Anticoagulant Obstetrics and Gynecology In vitro medicine.anatomical_structure Reproductive Medicine embryonic structures Immunology Female medicine.drug |
| Zdroj: | Gynecologic and Obstetric Investigation. 33:205-208 |
| ISSN: | 1423-002X 0378-7346 |
| DOI: | 10.1159/000294883 |
| Popis: | A soluble extract from human placenta was found to neutralize heparin in a factor Xa-dependent heparin assay system. In comparison with serum the antiheparin activity of placenta tissue is 10 times higher (extract from 1 g of placenta neutralizes 8.94 +/- 3.31 IU of heparin; 1 ml of serum approximately 1 IU). The substance neutralizing heparin has not been identified, but it has been found that it is nondialyzable, is not adsorbed on heparin-Sepharose, and does not act progressively. It was suggested that the substance(s) responsible for the antiheparin effect in vitro might contribute to the failure of heparin to penetrate the placenta in vivo (placental barrier to heparin). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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